Vol 26, No 1 (2021)
Case report
Published online: 2021-01-22

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Potential alternative treatment approach for pediatric patient with diffusely infiltrative primary rhabdomyosarcoma of the liver

Rushil Patel1, John Roberson2, Devina Prakash3, Rina Meyer3, Laura Hogan3, Christeen Azmy3, Valmore Suprenant4, Samuel Ryu2, Alexander Stessin2
Rep Pract Oncol Radiother 2021;26(1):143-148.

Abstract

Primary hepatic rhabdomyosarcoma is rare, making decisions regarding locoregional management with resection and/or conventional radiation difficult. We present a novel treatment approach for a pediatric patient diagnosed with rhabdomyosarcoma diffusely involving the liver. This patient underwent treatment with yttrium-90 (Y-90) microspheres followed by external beam radiation therapy (EBRT) to residual disease, interdigitated with systemic chemotherapy. Initial post-radiation imaging showed significant response to treatment, and she experienced minimal acute toxicities and no long-term toxicities. She developed recurrent PET-avid disease 23 months after Y-90 treatment, necessitating further local and continued systemic therapies. We report on the tumor control following Y-90 and EBRT treatment.

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