open access

Vol 26, No 1 (2021)
Technical note
Published online: 2021-01-22
Submitted: 2021-01-08
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Gonadal-sparing total body irradiation with the use of helical tomotherapy for nonmalignant indications

Khaled Dibs, Austin J. Sim, Jose A. Penagaricano, Kujtim Latifi, Genevieve A. Garcia, Julia A. Peters, Michael L. Nieder, Sungjune Kim, Timothy J. Robinson
DOI: 10.5603/RPOR.a2021.0006
·
Rep Pract Oncol Radiother 2021;26(1):153-158.

open access

Vol 26, No 1 (2021)
Technical Notes
Published online: 2021-01-22
Submitted: 2021-01-08

Abstract

Background: The aim was to demonstrate the feasibility and technique of gonadal sparing total body irradiation (TBI) with helical tomotherapy. Total body irradiation is a common part of the conditioning regimen prior to allogeneic stem cell transplantation. Shielding or dose-reduction to the gonads is often desired to preserve fertility, particularly in young patients undergoing transplant for non-malignant indications. Helical tomotherapy (HT) has been shown to be superior to traditional TBI delivery for organ at risk (OAR) doses and dose homogeneity.

Materials and methods: We present two representative cases (one male and one female) to illustrate the feasibility of this technique, each of whom received 3Gy in a single fraction prior to allogeneic stem cell transplant for benign indications. The planning target volume (PTV) included the whole body with a subtraction of OARs including the lungs, heart, and brain (each contracted by 1cm) as well as the gonads (testicles expanded by 5 cm and ovaries expanded by 0.5 cm).

Results: For the male patient we achieved a homogeneity index of 1.35 with a maximum and median planned dose to the testes of 0.53 Gy and 0.35 Gy, respectively. In-vivo dosimetry demonstrated an actual received dose of 0.48 Gy. For the female patient we achieved a homogeneity index of 1.13 with a maximum and median planned dose to the ovaries of 1.66 Gy and 0.86 Gy, respectively.

Conclusion: Gonadal sparing TBI is feasible and deliverable using HT in patients with non-malignant diseases requiring TBI as part of a pre-stem cell transplant conditioning regimen.

Abstract

Background: The aim was to demonstrate the feasibility and technique of gonadal sparing total body irradiation (TBI) with helical tomotherapy. Total body irradiation is a common part of the conditioning regimen prior to allogeneic stem cell transplantation. Shielding or dose-reduction to the gonads is often desired to preserve fertility, particularly in young patients undergoing transplant for non-malignant indications. Helical tomotherapy (HT) has been shown to be superior to traditional TBI delivery for organ at risk (OAR) doses and dose homogeneity.

Materials and methods: We present two representative cases (one male and one female) to illustrate the feasibility of this technique, each of whom received 3Gy in a single fraction prior to allogeneic stem cell transplant for benign indications. The planning target volume (PTV) included the whole body with a subtraction of OARs including the lungs, heart, and brain (each contracted by 1cm) as well as the gonads (testicles expanded by 5 cm and ovaries expanded by 0.5 cm).

Results: For the male patient we achieved a homogeneity index of 1.35 with a maximum and median planned dose to the testes of 0.53 Gy and 0.35 Gy, respectively. In-vivo dosimetry demonstrated an actual received dose of 0.48 Gy. For the female patient we achieved a homogeneity index of 1.13 with a maximum and median planned dose to the ovaries of 1.66 Gy and 0.86 Gy, respectively.

Conclusion: Gonadal sparing TBI is feasible and deliverable using HT in patients with non-malignant diseases requiring TBI as part of a pre-stem cell transplant conditioning regimen.

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Keywords

gonadal sparing; helical tomotherapy; marrow transplantation

About this article
Title

Gonadal-sparing total body irradiation with the use of helical tomotherapy for nonmalignant indications

Journal

Reports of Practical Oncology and Radiotherapy

Issue

Vol 26, No 1 (2021)

Article type

Technical note

Pages

153-158

Published online

2021-01-22

DOI

10.5603/RPOR.a2021.0006

Bibliographic record

Rep Pract Oncol Radiother 2021;26(1):153-158.

Keywords

gonadal sparing
helical tomotherapy
marrow transplantation

Authors

Khaled Dibs
Austin J. Sim
Jose A. Penagaricano
Kujtim Latifi
Genevieve A. Garcia
Julia A. Peters
Michael L. Nieder
Sungjune Kim
Timothy J. Robinson

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