Vol 9, No 1 (2023)
Review paper
Published online: 2023-03-21

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Methotrexate: Safe and effective

Magdalena Chudala1, Anna Kwaśniewska1, Beata Ochocka-Wojciechowska1, Wojciech Romanowski1
Rheumatology Forum 2023;9(1):23-28.

Abstract

Rheumatoid arthritis (RA) is the most common systemic connective tissue disease. The prevalence of RA in the general population is 0.3–1.5% (in Europe 0.8% in the adult population), with women affected 3 times more often. The first clinical description of the disease was made in 1859 by Garrod. More than 100 years later, methotrexate was used for the first time in RA therapy (in 1951). To this day, it is the primary drug in the therapy of this disease, as well as many other autoimmune and cancer diseases. The article presents the most important information on the use of methotrexate and the results of a study conducted at the local Center, confirming the safety of using the drug.

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References

  1. Terapia w chorobach reumatycznych. PZWL Wydawnictwo Lekarskie, Warszawa 2018: Warszawa.
  2. Tłustochowicz W. Metotreksat — zastosowanie w reumatologii i dermatologii. Termedia Wydawnictwo Medyczne,, Poznań 2014.
  3. Interna Szczeklika. Medycyna Praktyczna, Kraków 2021.
  4. Fraenkel L, Bathon JM, England BR, et al. 2021 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis. Arthritis Care Res (Hoboken). 2021; 73(7): 924–939.
  5. Charakterystyka produktu leczniczego Methotrexat-Ebewe 2013.
  6. Salliot C, van der Heijde D. Long-term safety of methotrexate monotherapy in patients with rheumatoid arthritis: a systematic literature research. Ann Rheum Dis. 2008; 68(7): 1100–1104.
  7. Kompendium Leków w Nefrologii. Via Medica, Gdańsk 2013.
  8. Goodman SM, Springer BD, Chen AF, et al. 2022 American College of Rheumatology/American Association of Hip and Knee Surgeons guideline for the perioperative management of antirheumatic medication in patients with rheumatic diseases undergoing elective total hip or total knee arthroplasty. Arthritis Care Res (Hoboken). 2022; 74(9): 1399–1408.
  9. Elert-Kopeć S, Tłustochowicz M, Załucka L. Stężenie metotreksatu w erytrocycie a aktywność procesu chorobowego u chorych na reumatoidalne zapalenie stawów. Reumatologia. 2013; 51(5): 370–374.
  10. Smolen JS, Landewé RBM, Bijlsma JW, et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2019 update. Ann Rheum Dis. 2020; 79(6): 685–699.
  11. Nieprzestrzeganie zaleceń terapeutycznych: od przyczyn do praktycznych rozwiązań, Index Copernicus 2015.
  12. Choi HK, Hernán MA, Seeger JD, et al. Methotrexate and mortality in patients with rheumatoid arthritis: a prospective study. Lancet. 2002; 359(9313): 1173–1177.