Vol 7, No 1 (2021)
Review paper
Published online: 2021-05-20
Rola odpowiedzi przeciwwirusowej z udziałem interferonów w patogenezie chorób autoimmunologicznych i nowe możliwości terapeutyczne
DOI: 10.5603/FR.2021.0004
Forum Reumatol 2021;7(1):19-26.
Abstract
Interferony to szeroka grupa cytokin biorących udział w nieswoistej odpowiedzi immunologicznej, stanowią ważny czynnik patogenetyczny odpowiedzialny za powstawanie oraz przebieg kliniczny licznych chorób autoimmunologicznych. W ostatnich latach opisano i zdefiniowano zjawisko regulacji wielu genów odpowiedzialnych za procesy zapalne i autoimmunologiczne określane wspólną nazwą sygnatury interferonu. W niniejszej pracy dokonano przeglądu znaczenia interfonów w patogenezie chorób autoimmunologicznych z uwzględnieniem terapeutycznych możliwości regulacji odpowiedzi zapalnej zależnej od interferonów
Keywords: interferonyukładowe choroby tkanki łącznejautoimmunizacjasygnatura interferonu
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