Vol 4, No 3 (2018)
Review paper
Published online: 2018-10-26
Witamina K — kontrowersje
DOI: 10.5603/FR.2018.0002
Forum Reumatol 2018;4(3):152-157.
Abstract
Osteoporoza jest poważną chorobą powodującą wystąpienie znacznej niepełnosprawności w populacji osób starszych. W prewencji i leczeniu tej choroby, oprócz modyfikacji stylu życia i leczenia antyresorpcyjnego, podstawowe znaczenia ma utrzymanie prawidłowej gospodarki mineralnej. W ciągu ostatnich 20 lat pojawiły się doniesienia wskazujące na rolę witaminy K w tym procesie. Celem niniejszego opracowania był krytyczny przegląd tych doniesień, ze szczególnym uwzględnieniem znaczenia witaminy K w prewencji osteoporozy.
Forum Reumatol. 2018, tom 4, nr 3: 152–157
Keywords: witamina Kosteokalcynaosteoporoza
References
- Palermo A, Tuccinardi D, D'Onofrio L, et al. Vitamin K and osteoporosis: Myth or reality? Metabolism. 2017; 70: 57–71.
- Vermeer C. Vitamin K: the effect on health beyond coagulation - an overview. Food Nutr Res. 2012; 56.
- Elder SJ, Haytowitz DB, Howe J, et al. Vitamin k contents of meat, dairy, and fast food in the u.s. Diet. J Agric Food Chem. 2006; 54(2): 463–467.
- Shearer MJ, Fu X, Booth SL. Vitamin K nutrition, metabolism, and requirements: current concepts and future research. Adv Nutr. 2012; 3(2): 182–195.
- Maillard C, Berruyer M, Serre CM, et al. Protein-S, a vitamin K-dependent protein, is a bone matrix component synthesized and secreted by osteoblasts. Endocrinology. 1992; 130(3): 1599–1604.
- Lombardi G, Perego S, Luzi L, et al. A four-season molecule: osteocalcin. Updates in its physiological roles. Endocrine. 2015; 48(2): 394–404.
- Kobayashi S, Shiraki M, Takaoka K. [Concurrent treatment of osteoporosis including vitamin K]. Clin Calcium. 2007; 17(11): 1731–1737.
- Hamidi MS, Gajic-Veljanoski O, Cheung AM. Vitamin K and bone health. J Clin Densitom. 2013; 16(4): 409–413.
- Hamidi MS, Cheung AM. Vitamin K and musculoskeletal health in postmenopausal women. Mol Nutr Food Res. 2014; 58(8): 1647–1657.
- Hodges SJ, Akesson K, Vergnaud P, et al. Circulating levels of vitamins K1 and K2 decreased in elderly women with hip fracture. J Bone Miner Res. 1993; 8(10): 1241–1245.
- Ikeda Y, Iki M, Morita A, et al. Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study. J Nutr. 2006; 136(5): 1323–1328.
- Booth SL, Broe KE, Peterson JW, et al. Associations between vitamin K biochemical measures and bone mineral density in men and women. J Clin Endocrinol Metab. 2004; 89(10): 4904–4909.
- Fang Y, Hu C, Tao X, et al. Effect of vitamin K on bone mineral density: a meta-analysis of randomized controlled trials. J Bone Miner Metab. 2012; 30(1): 60–68.
- Rejnmark L, Vestergaard P, Charles P, et al. No effect of vitamin K1 intake on bone mineral density and fracture risk in perimenopausal women. Osteoporos Int. 2006; 17(8): 1122–1132.
- Huang ZB, Wan SL, Lu YJ, et al. Does vitamin K2 play a role in the prevention and treatment of osteoporosis for postmenopausal women: a meta-analysis of randomized controlled trials. Osteoporos Int. 2015; 26(3): 1175–1186.
- Cockayne S, Adamson J, Lanham-New S, et al. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. 2006; 166(12): 1256–1261.
- Inoue T, Fujita T, Kishimoto H, et al. Randomized controlled study on the prevention of osteoporotic fractures (OF study): a phase IV clinical study of 15-mg menatetrenone capsules. J Bone Miner Metab. 2009; 27(1): 66–75.
- Levinger I, Brennan-Speranza TC, Zulli A, et al. Multifaceted interaction of bone, muscle, lifestyle interventions and metabolic and cardiovascular disease: role of osteocalcin. Osteoporos Int. 2017; 28(8): 2265–2273.
- Shea MK, Holden RM. Vitamin K status and vascular calcification: evidence from observational and clinical studies. Adv Nutr. 2012; 3(2): 158–165.
- Holmes MV, Hunt BJ, Shearer MJ. The role of dietary vitamin K in the management of oral vitamin K antagonists. Blood Rev. 2012; 26(1): 1–14.
- Namba S, Yamaoka-Tojo M, Hashikata T, et al. Long-term warfarin therapy and biomarkers for osteoporosis and atherosclerosis. BBA Clin. 2015; 4: 76–80.
- Jamal SA, Browner WS, Bauer DC, et al. Warfarin use and risk for osteoporosis in elderly women. Study of Osteoporotic Fractures Research Group. Ann Intern Med. 1998; 128(10): 829–832.
- Mahtani KR, Heneghan CJ, Nunan D, et al. Vitamin K for improved anticoagulation control in patients receiving warfarin. Cochrane Database Syst Rev. 2014(5): CD009917.
- Iwamoto J. Vitamin K(2) therapy for postmenopausal osteoporosis. Nutrients. 2014; 6(5): 1971–1980.
