Vol 17, No 3 (2020)
Review paper
Get Citation

Citalopram: an SSRI antidepressant that has been rediscovered

Andrzej Czernikiewicz, Tomasz Horoch
DOI: 10.5603/PSYCH.2020.0020
·
Psychiatria 2020;17(3):130-133.

paid access

Vol 17, No 3 (2020)
Prace poglądowe - nadesłane

Abstract

Citalopram is the most selective molecule in the class of selective serotonin reuptake inhibitors (SSRIs), except its active
enantiomer S-citalopram. It belongs to the group of antidepressant and anxiolytic drugs, which is currently the standard
in the treatment of depressive disorders and anxiety disorders with panic attacks, especially for the elderly. There is
a lower risk of adverse interactions with other drugs because citalopram is metabolized by several CYP isoenzymes.
The risk of sexual dysfunction caused by citalopram appears to be relatively smaller in comparison with other SSRIs.

Abstract

Citalopram is the most selective molecule in the class of selective serotonin reuptake inhibitors (SSRIs), except its active
enantiomer S-citalopram. It belongs to the group of antidepressant and anxiolytic drugs, which is currently the standard
in the treatment of depressive disorders and anxiety disorders with panic attacks, especially for the elderly. There is
a lower risk of adverse interactions with other drugs because citalopram is metabolized by several CYP isoenzymes.
The risk of sexual dysfunction caused by citalopram appears to be relatively smaller in comparison with other SSRIs.

Get Citation

Keywords

citalopram, antidepressants, SSRIs

About this article
Title

Citalopram: an SSRI antidepressant that has been rediscovered

Journal

Psychiatria (Psychiatry)

Issue

Vol 17, No 3 (2020)

Article type

Review paper

Pages

130-133

DOI

10.5603/PSYCH.2020.0020

Bibliographic record

Psychiatria 2020;17(3):130-133.

Keywords

citalopram
antidepressants
SSRIs

Authors

Andrzej Czernikiewicz
Tomasz Horoch

References (26)
  1. Landowski J. Citalopram (cipramil) ambulatoryjnej monoterapii zespołów depresyjnych. Psychiatria Polska. 2000; 34(3): suplement.
  2. Stahl SM. Prescriber’s guide Antidepressants. Fifth edition. Cambridge University Press 2014.
  3. Bazire S. Przewodnik leków psychotropowych. Via Medica, Gdańsk 2014.
  4. Hochstrasser B, Isaksen PM, Lauritzen L, et al. Prophylactic Effect of Citalopram in Unipolar, Recurrent Depression: Placebo-Controlled Study of Maintenance Therapy . Br J Psychiatry. 2001; 178: 304–310.
  5. Klysner i wsp., Br J Psychiatry 2002; 181: 29–35; przegląd Appelberg, EBMH 2003: 6: 24.
  6. Cipriani A, Purgato M, Furukawa TA. Citalopram versus other anti-depressive agents for depression . Cochrane Database Syst Rev. 2012; 7(7): CD006534.
  7. Ou JJ, Xun GL, Wu RR, et al. Efficacy and safety of escitalopram versus citalopram in major depressive disorder: a 6-week, multicenter, randomized, double-blind, flexible-dose study. Psychopharmacology (Berl). 2011; 213(2-3): 639–646.
  8. Schaffer A, Zuker E, Levitt A. Randomized, double-blind pilot trial comparing lamotrigine versus citalopram for the treatment of bipolar depression. Schaffer i wsp , J Affect Disord. 2006; 96: 95–9.
  9. Perna G, Bertani A, Caldirola D, et al. A comparison of citalopram and paroxetine in the treatment of panic disorder, a randomised single blind study. Pharmacopsychiatry. 2001; 34 : 85–90.
  10. Charakterystyka Produktu Leczniczego Citaxin 20 mg, tabletki powlekane, zatw. 04.2020.
  11. Brosen K, Naranjo CA. Review of pharmacokinetic and pharmacodynamic interaction studies with citalopram. Eur Neuropsychopharmacol. 2001; 11: 275–283.
  12. Padala PR, Padala K, Sadiq H. Urinary obstruction with citalopram and aripiprazole combination in an elderly patient. J Clin Psychopharmacol. 2006; 26: 667–678.
  13. Milne R, Goa K. Citalopram. A Review of its pharmacodynamics and pharmacokinetic properties, and therapeutic potential in deppresion illness . Drugs. 1991; 41(3): 450–477.
  14. Avenoso A, Facciola G, Scordo MG. No effect of citalopram on plasma levels of clozapine, risperidone and their active metabolites in patients with chronic schizophrenia. Clin Drug Investigation . 1998; 16: 393–398.
  15. Blaschke D, Parvani AD, Huemer M. Torsade de pointes during combined treatment with rispridone and citalopram. Pharmacopsychiatry. 2007; 40(01): 294–295.
  16. Nolting A, Abramowitz W. Lack of interaction between citalopram and the CYP3A4 substrate triazolam. Pharmacother. 2000; 20: 750–755.
  17. Hall i wsp., J. Clin. Psychopharmacol. 2003; 23: 349–7).
  18. Molden E, Spigset ). [Interactions Between Metoprolol and Antidepressants]. Tidsskr Nor Laegeforen. 2011; 131: 1777–1779.
  19. Moller i wsp., J. Clin. Psychophamacol. 2001; 21: 493–9).
  20. Gram i wsp., Ther. Drug Monit. 1993; 15: 18–24).
  21. Preskorn i wsp., Br. J. Clin. Pharmacol. 1997; 44: 199–202).
  22. Sayal KS, Duncan-McConnell DA, McConnell HW. Psychotropic interactions with warfarin. Acta Psychiatr Scand. 2000; 102: 250–255.
  23. [źródło].
  24. [źródło].
  25. Cipriani A, Furukawa TA, Salanti G, et al. Multiple Meta-Analyses of New Generation Antidepressants (MANGA) Study Group. Mirtazapine versus other antidepressants in the acute-phase treatment of adults with major depression: systematic review and meta-analysis. J Clin Psychiatry. 2008; 69(9): 1404–1415.
  26. [źródło].

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest Via Medica sp. z o.o. sp. komandytowa, ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl