- Clinical vignette
Inferior vena cava thrombus after veno-arterial ECMO therapy treated with mechanical thrombectomy in an LVAD patient
Tomasz Urbanowicz1, Aleksander Araszkiewicz2, Paweł Marcinkowski1, Sylwia Sławek-Szmyt2, Bartłomiej Perek1, Maciej Walczak1, Marek Jemielity1
1Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Poznań, Poland
21st Cardiology Department, Poznan University of Medical Sciences, Poznań, Poland
A 53-year-old male with dilated cardiomyopathy was admitted due to heart failure deterioration that progressed to a cardiogenic shock refractory to medical therapy and intra-aortic contrapulsation.
Peripheral veno-arterial extracorporeal membrane oxygenation (v-a ECMO) was applied. During ECMO therapy, the active clotting time ranged 160–220 seconds, but the platelet count dropped from 244 to 24 109/l despite a negative result of testing for anti-PF4/Heparin antibodies.
The next day, left ventricular mechanical support (LVAD) (Heartmate 3, Abbott, Plymouth, MN, USA) implantation was performed through median sternotomy. Postoperatively, transthoracic echocardiography in the intensive care unit revealed a large, free-floating thrombus in the inferior vena cava (IVC) (Figure 1A). Venous access was gained through the right femoral vein. Venography showed a large thrombus in the IVC (Supplementary material, Video S1). The Sentrant 20 F vascular sheath (Medtronic, Minneapolis, MN, USA) was inserted and subsequently, the Indigo 8F CAT XTRQ (Penumbra, Alameda, CA, USA) catheter was placed distally to the face of the clot. Aspiration was applied to the Indigo catheter via the Penumbra Engine until CAT8 became occluded. CAT8 was subsequently removed under continuous aspiration to ensure the clot remained engaged in the catheter tip and the 11 cm long thrombus (Figure 1B) was extracted out via a large-sized vascular sheath. No complications occurred from the procedure.
Thromboembolic complications [1] are the leading cause of morbidity in v-a ECMO that is indicated in refractory cardiogenic shock [2] as a bridge to long-term LVAD.
We present the first, to our knowledge, description of successful removal of thrombus from the inferior vena cava, which occurred as a complication of ECMO therapy.
Most probably, the thrombus formed during ECMO therapy and the platelet count drop was an ominous indicator of this complication. It was found shortly after LVAD implantation as it migrated from the tip of the venous cannula after removal from the femoral vein. Alternative methods of thrombectomy were discussed since the surgical intervention was extremely risky.
Transcatheter thrombectomy with material aspiration in acute pulmonary embolism was found to be feasible and safe [3]. We applied an Indigo device inserted through a large-sized vascular sheath and used the XTRACT technique described in the PRISM trial in patients with peripheral arterial thromboembolism [4]. Our treatment was safe and effective. The therapy represents a viable and encouraging option in patients with “thrombus in-transit” in the IVC.
Supplementary material
Supplementary material is available at https://journals.viamedica.pl/kardiologia_polska.
Article information
Conflict of interest: None declared.
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Correspondence to:
Tomasz Urbanowicz, MD, PhD,
Cardiac Surgery and Transplantology Department,
Poznan University of Medical Sciences,
Długa 1/2, 61–001 Poznań, Poland,
phone: +48 618 549 210,
e-mail: tomasz.urbanowicz@skpp.edu.pl
Copyright by the Author(s), 2022
DOI: 10.33963/KP.a2021.0083
Received: July 8, 2021
Accepted: August 6, 2021
Early publication date: August 6, 2021