Vol 80, No 1 (2022)
Clinical vignette
Published online: 2021-10-19

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  • „ Clinical vignette

Inferior vena cava thrombus after veno-arterial ECMO therapy treated with mechanical thrombectomy in an LVAD patient

Tomasz Urbanowicz1, Aleksander Araszkiewicz2, Paweł Marcinkowski1, Sylwia Sławek-Szmyt2, Bartłomiej Perek1, Maciej Walczak1, Marek Jemielity1

1Cardiac Surgery and Transplantology Department, Poznan University of Medical Sciences, Poznań, Poland

21st Cardiology Department, Poznan University of Medical Sciences, Poznań, Poland

A 53-year-old male with dilated cardiomyopathy was admitted due to heart failure deterioration that progressed to a cardiogenic shock refractory to medical therapy and intra-aortic contrapulsation.

Peripheral veno-arterial extracorporeal membrane oxygenation (v-a ECMO) was applied. During ECMO therapy, the active clotting time ranged 160220 seconds, but the platelet count dropped from 244 to 24 109/l despite a negative result of testing for anti-PF4/Heparin antibodies.

The next day, left ventricular mechanical support (LVAD) (Heartmate 3, Abbott, Ply­mouth, MN, USA) implantation was performed through median sternotomy. Postoperatively, transthoracic echocardiography in the intensive care unit revealed a large, free-floating thrombus in the inferior vena cava (IVC) (Figure 1A). Venous access was gained through the right femoral vein. Venography showed a large thrombus in the IVC (Supp­lementary material, Video S1). The Sentrant 20 F vascular sheath (Medtronic, Minneapolis, MN, USA) was inserted and subsequently, the Indigo 8F CAT XTRQ (Penumbra, Alameda, CA, USA) catheter was placed distally to the face of the clot. Aspiration was applied to the Indigo catheter via the Penumbra Engine until CAT8 became occluded. CAT8 was subsequently removed under continuous aspiration to ensure the clot remained engaged in the catheter tip and the 11 cm long thrombus (Figure 1B) was extracted out via a large-sized vascular sheath. No complications occurred from the procedure.

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Figure 1. A. Tubular formation in the vena cava. B. Thrombus removed during thrombectomy

Thromboembolic complications [1] are the leading cause of morbidity in v-a ECMO that is indicated in refractory cardiogenic shock [2] as a bridge to long-term LVAD.

We present the first, to our knowledge, description of successful removal of thrombus from the inferior vena cava, which occurred as a complication of ECMO therapy.

Most probably, the thrombus formed during ECMO therapy and the platelet count drop was an ominous indicator of this complication. It was found shortly after LVAD implantation as it migrated from the tip of the venous cannula after removal from the femoral vein. Alternative methods of thrombectomy were discussed since the surgical intervention was extremely risky.

Transcatheter thrombectomy with material aspiration in acute pulmonary embolism was found to be feasible and safe [3]. We applied an Indigo device inserted through a large-sized vascular sheath and used the XTRACT technique described in the PRISM trial in patients with peripheral arterial thromboembolism [4]. Our treatment was safe and effective. The therapy represents a viable and encouraging option in patients with “thrombus in-transit” in the IVC.

Supplementary material

Supplementary material is available at https://journals.viamedica.pl/kardiologia_polska.

Article information

REFERENCES

  1. 1. Murphy DA, Hockings LE, Andrews RK, et al. Extracorporeal membrane oxygenation-hemostatic complications. Transfus Med Rev. 2015; 29(2): 90101, doi: 10.1016/j.tmrv.2014.12.001, indexed in Pubmed: 25595476.
  2. 2. Chakaramakkil MJ, Sivathasan C. ECMO and short-term support for cardiogenic shock in heart failure. Curr Cardiol Rep. 2018; 20(10): 87, doi: 10.1007/s11886-018-1041-4, indexed in Pubmed: 30116917.
  3. 3. Li K, Cui M, Zhang K, et al. Treatment of acute pulmonary embolism using rheolytic thrombectomy. EuroIntervention. 2021; 17(2): e158e166, doi: 10.4244/EIJ-D-20-00259, indexed in Pubmed: 32863245.
  4. 4. Saxon RR, Benenati JF, Teigen C, et al. PRISM Trialists. Utility of a power aspiration-based extraction technique as an initial and secondary approach in the treatment of peripheral arterial thromboembolism: results of the multicenter PRISM trial. J Vasc Interv Radiol. 2018; 29(1): 92100, doi: 10.1016/j.jvir.2017.08.019, indexed in Pubmed: 29128156.

Correspondence to:

Tomasz Urbanowicz, MD, PhD,

Cardiac Surgery and Transplantology Department,

Poznan University of Medical Sciences,

Długa 1/2, 61–001 Poznań, Poland,

phone: +48 618 549 210,

e-mail: tomasz.urbanowicz@skpp.edu.pl

Copyright by the Author(s), 2022

DOI: 10.33963/KP.a2021.0083

Received: July 8, 2021

Accepted: August 6, 2021

Early publication date: August 6, 2021