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Autosomal dominant neovascular inflammatory vitreoretinopathy — a review
Affiliations- Department of General Ophthalmology and Pediatric Ophthalmology Service, Medical University of Lublin, Lublin, Poland
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Abstract
Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a hereditary autoimmune disorder of the eye caused by mutations in the CAPN5 gene. It is characterized by non-specific uveitis in the anterior chamber and vitreous leading to panuveitis, iris and retinal neovascularization, cystoid macular edema, abnormal retinal pigmentation, vitreous hemorrhage, intraocular fibrosis, membrane formation and tractional retinal detachment. ADNIV is a progressive disease leading to complete blindness despite of treatment. Confirmation is made by genetic analysis demonstrating mutations of the CAPN5 gene.
Abstract
Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a hereditary autoimmune disorder of the eye caused by mutations in the CAPN5 gene. It is characterized by non-specific uveitis in the anterior chamber and vitreous leading to panuveitis, iris and retinal neovascularization, cystoid macular edema, abnormal retinal pigmentation, vitreous hemorrhage, intraocular fibrosis, membrane formation and tractional retinal detachment. ADNIV is a progressive disease leading to complete blindness despite of treatment. Confirmation is made by genetic analysis demonstrating mutations of the CAPN5 gene.
Keywords
autosomal dominant neovascular inflammatory vitreoretinopathy; ADNIV; uveitis; neovascularization; proliferative vitreoretinopathy; cystoid macular edema; CAPN5; calpain-5
About this articleTitle
Autosomal dominant neovascular inflammatory vitreoretinopathy — a review
Journal
Issue
Vol 4 (2019): Continuous Publishing
Article type
Review paper
Pages
15-21
Published online
2019-05-21
Page views
727
Article views/downloads
1019
DOI
Bibliographic record
Ophthalmol J 2019;4:15-21.
Keywords
autosomal dominant neovascular inflammatory vitreoretinopathy
ADNIV
uveitis
neovascularization
proliferative vitreoretinopathy
cystoid macular edema
CAPN5
calpain-5
Authors
Małgorzata A. Kowalczyk
Robert Rejdak
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