Vol 4 (2019): Continuous Publishing
Review paper
Published online: 2019-05-21

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Autosomal dominant neovascular inflammatory vitreoretinopathy — a review

Małgorzata A. Kowalczyk1, Robert Rejdak1
Ophthalmol J 2019;4:15-21.

Abstract

Autosomal dominant neovascular inflammatory vitreoretinopathy (ADNIV) is a hereditary autoimmune disorder of the eye caused by mutations in the CAPN5 gene. It is characterized by non-specific uveitis in the anterior chamber and vitreous leading to panuveitis, iris and retinal neovascularization, cystoid macular edema, abnormal retinal pigmentation, vitreous hemorrhage, intraocular fibrosis, membrane formation and tractional retinal detachment. ADNIV is a progressive disease leading to complete blindness despite of treatment. Confirmation is made by genetic analysis demonstrating mutations of the CAPN5 gene.

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