Adverse effect of UV radiation on eyes — a review
Abstract
The aim of this study is to discuss the association between ultraviolet radiation (UVR) and eye diseases. UVR which
reaches the surface of the Earth consists of 95% UVA and 5% of UVB. Both acute and chronic exposure to UVR
leads to pathological changes in the eye. There is strong evidence that UVR exposure causes photokeratitis, photoretinitis,
climatic droplet keratopathy, cataract, pterygium, squamous cell carcinoma of cornea and conjunctiva,
cancer of the eyelids (squamous cell and basal cell carcinoma). Association between UVR and pinguecula, AMD
(age-related macular degeneration) and melanoma of the eyeball is ambiguous. UVR exposure occurs all day and all
year long, which is why eye protection is necessary to avoid diseases induced by UVR. In particular childrens’ eyes
should be protected from the sun. Efficient protection is provided by accurate clothing, hats, eyeglasses or contact
lenses blocking UV light.
Keywords: ophthalmologyultraviolet lightcataractAMDmelanoma
References
- de Gruijl FR, Longstreth J, Norval M, et al. Health effects from stratospheric ozone depletion and interactions with climate change. Photochem Photobiol Sci. 2003; 2(1): 16–28.
- Sasaki H, Sakamoto Y, Schnider C, et al. UV-B exposure to the eye depending on solar altitude. Eye Contact Lens. 2011; 37(4): 191–195.
- Behar-Cohen F, Baillet G, de Ayguavives T, et al. Ultraviolet damage to the eye revisited: eye-sun protection factor (E-SPF®), a new ultraviolet protection label for eyewear. Clin Ophthalmol. 2014; 8: 87–104.
- Sliney DH. Physical factors in cataractogenesis: ambient ultraviolet radiation and temperature. Invest Ophthalmol Vis Sci. 1986; 27(5): 781–790.
- Young S, Sands J. Sun and the eye: prevention and detection of light-induced disease. Clin Dermatol. 1998; 16(4): 477–485.
- Weale RA. Age and the transmittance of the human crystalline lens. J Physiol. 1988; 395: 577–587.
- Yin VT, Merritt HA, Sniegowski M, et al. Eyelid and ocular surface carcinoma: diagnosis and management. Clin Dermatol. 2015; 33(2): 159–169.
- Dekmezian MS, Cohen PR, Sami M, et al. Malignancies of the eyelid: a review of primary and metastatic cancers. Int J Dermatol. 2013; 52(8): 903–926.
- Rigel DS. Cutaneous ultraviolet exposure and its relationship to the development of skin cancer. J Am Acad Dermatol. 2008; 58(5 Suppl 2): S129–S132.
- Kwa RE, Campana K, Moy RL. Biology of cutaneous squamous cell carcinoma. J Am Acad Dermatol. 1992; 26(1): 1–26.
- Gallagher RP, Hill GB, Bajdik CD, et al. Sunlight exposure, pigmentation factors, and risk of nonmelanocytic skin cancer. II. Squamous cell carcinoma. Arch Dermatol. 1995; 131(2): 164–169.
- Rosso S, Zanetti R, Martinez C, et al. The multicentre south European study 'Helios'. II: Different sun exposure patterns in the aetiology of basal cell and squamous cell carcinomas of the skin. Br J Cancer. 1996; 73(11): 1447–1454.
- Kricker A, Armstrong BK, English DR, et al. Does intermittent sun exposure cause basal cell carcinoma? a case-control study in Western Australia. Int J Cancer. 1995; 60(4): 489–494.
- Gallagher RP, Hill GB, Bajdik CD, et al. Sunlight exposure, pigmentary factors, and risk of nonmelanocytic skin cancer. I. Basal cell carcinoma. Arch Dermatol. 1995; 131(2): 157–163.
- Taylor HR. Aetiology of climatic droplet keratopathy and pterygium. Br J Ophthalmol. 1980; 64(3): 154–163.
- Modenese A, Gobba F. Occupational Exposure to Solar Radiation at Different Latitudes and Pterygium: A Systematic Review of the Last 10 Years of Scientific Literature. Int J Environ Res Public Health. 2017; 15(1): pii: E37.
- Moran DJ, Hollows FC. Pterygium and ultraviolet radiation: a positive correlation. Br J Ophthalmol. 1984; 68(5): 343–346.
- Anbesse DH, Kassa T, Kefyalew B, et al. Prevalence and associated factors of pterygium among adults living in Gondar city, Northwest Ethiopia. PLoS One. 2017; 12(3): e0174450.
- Nemesure B, Wu SY, Hennis A, et al. Barbados Eye Studies Group. Nine-year incidence and risk factors for pterygium in the barbados eye studies. Ophthalmology. 2008; 115(12): 2153–2158.
- Le Q, Xiang J, Cui X, et al. Prevalence and associated factors of pinguecula in a rural population in Shanghai, Eastern China. Ophthalmic Epidemiol. 2015; 22(2): 130–138.
- Asokan R, Venkatasubbu RS, Velumuri L, et al. Prevalence and associated factors for pterygium and pinguecula in a South Indian population. Ophthalmic Physiol Opt. 2012; 32(1): 39–44.
- Cullen AP. Photokeratitis and other phototoxic effects on the cornea and conjunctiva. Int J Toxicol. 2002; 21(6): 455–464.
- Bergmanson JP. Corneal damage in photokeratitis — why is it so painful? Optom Vis Sci. 1990; 67(6): 407–413.
- Oliva MS, Taylor H. Ultraviolet radiation and the eye. Int Ophthalmol Clin. 2005; 45(1): 1–17.
- Suárez MF, Correa L, Crim N, et al. Climatic Droplet Keratopathy in Argentina: Involvement of Environmental Agents in Its Genesis Which Would Open the Prospect for New Therapeutic Interventions. Biomed Res Int. 2015; 2015: 527835.
- Pe'er J. Ocular surface squamous neoplasia. Ophthalmol Clin North Am. 2005; 18(1): 1–13, vii.
- Templeton AC, Hutt MS, Dodge OG, et al. Tumors of the eye and adnexa in Africans of Uganda. Cancer. 1967; 20(10): 1689–1698.
- Lee GA, Hirst LW. Incidence of ocular surface epithelial dysplasia in metropolitan Brisbane. A 10-year survey. Arch Ophthalmol. 1992; 110(4): 525–527.
- Sun EC, Fears TR, Goedert JJ. Epidemiology of squamous cell conjunctival cancer. Cancer Epidemiol Biomarkers Prev. 1997; 6(2): 73–77.
- Newton R, Ferlay J, Reeves G, et al. Effect of ambient solar ultraviolet radiation on incidence of squamous-cell carcinoma of the eye. Lancet. 1996; 347(9013): 1450–1451.
- Balasubramanian D. Ultraviolet radiation and cataract. J Ocul Pharmacol Ther. 2000; 16(3): 285–297.
- Cruickshanks KJ, Klein BE, Klein R. Ultraviolet light exposure and lens opacities: the Beaver Dam Eye Study. Am J Public Health. 1992; 82(12): 1658–1662.
- Delcourt C, Carrière I, Ponton-Sanchez A, et al. Light exposure and the risk of cortical, nuclear, and posterior subcapsular cataracts: the Pathologies Oculaires Liées à l'Age (POLA) study. Arch. Ophthalmol. 2000; 118(3): 385–392.
- West SK, Duncan DD, Muñoz B, et al. Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation project. JAMA. 1998; 280(8): 714–718.
- Sasaki H, Kawakami Y, Ono M, et al. Localization of Cortical Cataract in Subjects of Diverse Races and Latitude. Invest Opthalmol Vis Sci. 2003; 44(10): 4210–4214.
- Cruickshanks KJ, Klein R, Klein BE. Sunlight and age-related macular degeneration. The Beaver Dam Eye Study. Arch Ophthalmol. 1993; 111(4): 514–518.
- Roduit R, Schorderet DF. MAP kinase pathways in UV-induced apoptosis of retinal pigment epithelium ARPE19 cells. Apoptosis. 2008; 13(3): 343–353.
- Yam J, Kwok A. Ultraviolet light and ocular diseases. Int Ophthalmol. 2013; 34(2): 383–400.
- Klein R, Klein BE, Jensen SC, et al. Medication Use and the 5-Year Incidence of Early Age-Related Maculopathy. Arch Ophthalmol. 2001; 119(9): 1354–1359.
- Taylor HR, Munoz B, West S, et al. Visible light and risk of age-related macular degeneration. Trans Am Ophthalmol Soc. 1990; 88: 163–173.
- Taylor HR, West S, Muñoz B, et al. The long-term effects of visible light on the eye. Arch Ophthalmol. 1992; 110(1): 99–104.
- Darzins P, Mitchell P, Heller RF. Sun exposure and age-related macular degeneration. An Australian case-control study. Ophthalmology. 1997; 104(5): 770–776.
- Oliva MS, Taylor H. Ultraviolet radiation and the eye. Int Ophthalmol Clin. 2005; 45(1): 1–17.
- Wang JJ, Klein R, Smith W, et al. Cataract surgery and the 5-year incidence of late-stage age-related maculopathy: pooled findings from the Beaver Dam and Blue Mountains eye studies. Ophthalmology. 2003; 110(10): 1960–1967.
- McLaughlin CC, Wu XC, Jemal A, et al. Incidence of noncutaneous melanomas in the U.S. Cancer. 2005; 103(5): 1000–1007.
- Vajdic CM, Kricker A, Giblin M, et al. Sun exposure predicts risk of ocular melanoma in Australia. Int J Cancer. 2002; 101(2): 175–182.
- Pane AR, Hirst LW. Ultraviolet light exposure as a risk factor for ocular melanoma in Queensland, Australia. Ophthalmic Epidemiol. 2000; 7(3): 159–167.
- Seddon JM, Gragoudas ES, Glynn RJ, et al. Host factors, UV radiation, and risk of uveal melanoma. A case-control study. Arch Ophthalmol. 1990; 108(9): 1274–1280.
- Guénel P, Laforest L, Cyr D, et al. Occupational risk factors, ultraviolet radiation, and ocular melanoma: a case-control study in France. Cancer Causes Control. 2001; 12(5): 451–459.
- Rosenthal FS, Safran M, Taylor HR. The ocular dose of ultraviolet radiation from sunlight exposure. Photochem Photobiol. 1985; 42(2): 163–171.