Vol 2, No 3 (2017)
Case report
Published online: 2017-12-28

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Neurotrophic keratopathy — case reports analysis and management

Ioannis Mallias1, Panagiota Mylova, Anastasia Tassiopoulou
Ophthalmol J 2017;2(3):91-99.

Abstract

This is a case series of patients suffering from neurotrophic keratopathy. The main categorisation of the disease is discussed as well as the management that should be followed on each stage. Several cases of patients with neurotrophic keratopathy are analysed and the treatment (different on every patient) of them is presented. Newer substances that are beginning to be used in the treatment of neurotrophic keratopathy are discussed as well.

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References

  1. Sacchetti M, Lambiase A. Diagnosis and management of neurotrophic keratitis. Clin Ophthalmol. 2014; 8: 571–579.
  2. Kauffmann T, Bodanowitz S, Hesse L, et al. Corneal reinnervation after photorefractive keratectomy and laser in situ keratomileusis: an in vivo study with a confocal videomicroscope. Ger J Ophthalmol. 1996; 5(6): 508–512.
  3. Wilson SE. Laser in situ keratomileusis-induced (presumed) neurotrophic epitheliopathy. Ophthalmology. 2001; 108(6): 1082–1087.
  4. Wilson SE, Ambrósio R. Laser in situ keratomileusis-induced neurotrophic epitheliopathy. Am J Ophthalmol. 2001; 132(3): 405–406.
  5. Netto MV, Mohan RR, Ambrósio R, et al. Gene therapy in the cornea. Prog Retin Eye Res. 2005; 24(5): 537–559.
  6. Lin X, Xu B, Sun Y, et al. Comparison of deep anterior lamellar keratoplasty and penetrating keratoplasty with respect to postoperative corneal sensitivity and tear film function. Graefes Arch Clin Exp Ophthalmol. 2014; 252(11): 1779–1787.
  7. Wasilewski D, Mello GHR, Moreira H. Impact of collagen crosslinking on corneal sensitivity in keratoconus patients. Cornea. 2013; 32(7): 899–902.
  8. Banerjee PJ, Chandra A, Sullivan PM, et al. Neurotrophic corneal ulceration after retinal detachment surgery with retinectomy and endolaser: a case series. JAMA Ophthalmol. 2014; 132(6): 750–752.
  9. Tinley CG, Gray RH. Routine, single session, indirect laser for proliferative diabetic retinopathy. Eye (Lond). 2009; 23(9): 1819–1823.
  10. Lockwood A, Hope-Ross M, Chell P. Neurotrophic keratopathy and diabetes mellitus. Eye (Lond). 2006; 20(7): 837–839.
  11. Mackie IA. Neuroparalytic keratitis. In: Fraunfelder F, Roy FH, Meyer SM. ed. Current ocular therapy. WB Saunders, Philadelphia, PA: 1995: 452–454.
  12. Hersh PS, Rice BA, Baer JC, et al. Topical nonsteroidal agents and corneal wound healing. Arch Ophthalmol. 1990; 108(4): 577–583.
  13. Jeng BH, Dupps WJ. Autologous serum 50% eyedrops in the treatment of persistent corneal epithelial defects. Cornea. 2009; 28(10): 1104–1108.
  14. Turkoglu E, Celik E, Alagoz G. A comparison of the efficacy of autologous serum eye drops with amniotic membrane transplantation in neurotrophic keratitis. Semin Ophthalmol. 2014; 29(3): 119–126.
  15. Bonini S, Rama P, Olzi D, et al. Neurotrophic keratitis. Eye (Lond). 2003; 17(8): 989–995.
  16. Aifa A, Gueudry J, Portmann A, et al. Topical treatment with a new matrix therapy agent (RGTA) for the treatment of corneal neurotrophic ulcers. Invest Ophthalmol Vis Sci. 2012; 53(13): 8181–8185.
  17. http://ophthalmologytimes.modernmedicine.com/ophthalmologytimes/news/cenegermin-receives-european-commission-marketing-authorization.
  18. Faulkner WJ, Varley GA. Corneal diagnostic techniques. In: Krachmer JH, Mannis MJ, Holland EJ. ed. Cornea. Elsevier/Mosby, Philadelphia 2005: 229–235.
  19. Aslanides IM, Selimis VD, Bessis NV, et al. A pharmacological modification of pain and epithelial healing in contemporary transepithelial all-surface laser ablation (ASLA). Clin Ophthalmol. 2015; 9: 685–690.