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Case report
Published online: 2022-03-08
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Immunotherapy with pembrolizumab in a patient with advanced non-small-cell lung cancer with high PD-L1 expression and MET exon 14 splice site mutation: a case report

Paulina Terlecka12, Paweł Krawczyk1, Anna Grenda1, Izabela Chmielewska1, Janusz Milanowski1
DOI: 10.5603/OCP.2022.0007
Affiliations
  1. Department of Pneumonology, Oncology, and Allergology, Medical University of Lublin, Poland
  2. Department of Endocrinology, Diabetology and Metabolic Diseases, Medical University of Lublin, Poland

open access

Ahead of print
CASE REPORTS
Published online: 2022-03-08

Abstract

Lung cancer is one of the major oncological problems in Poland. Pembrolizumab monotherapy can be applied as first-line treatment in patients with advanced non-small-cell lung cancer (NSCLC) with the expression of programmed death ligand 1 (PD-L1) in ≥ 50% of tumor cells. The article presents a case report of a female patient with advanced lung adenocarcinoma and high PD-L1 expression and an additional MET exon 14 skipping mutation. Despite the advanced stage of the disease, the patient benefited spectacularly from pembrolizumab administered following stereotactic radiotherapy for central nervous system (CNS) metastases. Partial remission followed by long-term stabilization of the disease was achieved. Unfortunately, the therapy was discontinued due to grade-3 pulmonary toxicity observed after 3 years of treatment. Despite the discontinuation of the pembrolizumab therapy, the disease has currently been stabilized and inflammatory changes have slowly resolved upon administration of corticosteroid.

Abstract

Lung cancer is one of the major oncological problems in Poland. Pembrolizumab monotherapy can be applied as first-line treatment in patients with advanced non-small-cell lung cancer (NSCLC) with the expression of programmed death ligand 1 (PD-L1) in ≥ 50% of tumor cells. The article presents a case report of a female patient with advanced lung adenocarcinoma and high PD-L1 expression and an additional MET exon 14 skipping mutation. Despite the advanced stage of the disease, the patient benefited spectacularly from pembrolizumab administered following stereotactic radiotherapy for central nervous system (CNS) metastases. Partial remission followed by long-term stabilization of the disease was achieved. Unfortunately, the therapy was discontinued due to grade-3 pulmonary toxicity observed after 3 years of treatment. Despite the discontinuation of the pembrolizumab therapy, the disease has currently been stabilized and inflammatory changes have slowly resolved upon administration of corticosteroid.

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Keywords

non-small cell lung cancer; immunotherapy; splice site mutation; MET gene; PD-L1 expression

About this article
Title

Immunotherapy with pembrolizumab in a patient with advanced non-small-cell lung cancer with high PD-L1 expression and MET exon 14 splice site mutation: a case report

Journal

Oncology in Clinical Practice

Issue

Ahead of print

Article type

Case report

Published online

2022-03-08

Page views

346

Article views/downloads

131

DOI

10.5603/OCP.2022.0007

Keywords

non-small cell lung cancer
immunotherapy
splice site mutation
MET gene
PD-L1 expression

Authors

Paulina Terlecka
Paweł Krawczyk
Anna Grenda
Izabela Chmielewska
Janusz Milanowski

References (18)
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