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Stevens-Johnson syndrome in breast cancer patient treated with ribociclib
Affiliations- Department of Oncology with Daily Unit, Tadeusz Koszarowski Cancer Center in Opole, Poland
- Department of Oncology, Institute of Medical Sciences, University of Opole, Poland
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Abstract
Introduction. Ribociclib is a cyclin-dependent kinase (CDK) inhibitor, widely used in patients with different types of cancer. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe immunologic skin reactions that lead to epidermal necrolysis followed by exfoliation with life-threatening consequences.
Case presentation. We present a case of a patient with metastatic breast cancer with SJS-like skin reaction during treatment with ribociclib and letrozole. The patient presented skin changes, typical clinical symptoms (with Nikolsky sign), and destruction of the epithelium by forming blisters and abscesses on pathological examination. The lesions covered about 30% of the skin surface, and they were scored as grade 4 according to CTCAE v. 5.0. After ribociclib discontinuation and supportive management, a gradual improvement of skin lesions was observed.
Conclusion. We present this case as there are only a few case reports on ribociclib-related Stevens-Johnson syndrome in the literature, and clinicians should be aware of the risk of this side effect.
Abstract
Introduction. Ribociclib is a cyclin-dependent kinase (CDK) inhibitor, widely used in patients with different types of cancer. Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe immunologic skin reactions that lead to epidermal necrolysis followed by exfoliation with life-threatening consequences.
Case presentation. We present a case of a patient with metastatic breast cancer with SJS-like skin reaction during treatment with ribociclib and letrozole. The patient presented skin changes, typical clinical symptoms (with Nikolsky sign), and destruction of the epithelium by forming blisters and abscesses on pathological examination. The lesions covered about 30% of the skin surface, and they were scored as grade 4 according to CTCAE v. 5.0. After ribociclib discontinuation and supportive management, a gradual improvement of skin lesions was observed.
Conclusion. We present this case as there are only a few case reports on ribociclib-related Stevens-Johnson syndrome in the literature, and clinicians should be aware of the risk of this side effect.
Keywords
ribociclib; breast cancer; Stevens-Johnson syndrome; toxic epidermal necrolysis
About this articleTitle
Stevens-Johnson syndrome in breast cancer patient treated with ribociclib
Journal
Issue
Article type
Case report
Published online
2022-03-31
Page views
156
Article views/downloads
151
DOI
10.5603/OCP.2022.0004
Keywords
ribociclib
breast cancer
Stevens-Johnson syndrome
toxic epidermal necrolysis
Authors
Adam Kowalczyk
Barbara Radecka
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