open access

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Case report
Published online: 2021-04-07
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Genetically burdened transgender man during gender reassignment process with two primary neoplasms: a case report

Agnieszka Bobola, Anita Gorzelak-Magiera, Katarzyna Steinhof-Radwańska, Andrzej Lorek, Michał Kliber, Iwona Gisterek
DOI: 10.5603/OCP.2021.0009

open access

Ahead of print
CASE REPORT
Published online: 2021-04-07

Abstract

Transgender is defined as an incongruence between the assigned at birth sex and an experienced gender identity. The biological sex is neither familiar nor acceptable to transgender people. Gender-affirming hormone treatment (GHT) is a multidisciplinary approach aiming to develop and maintain physical characteristics of the desirable sex. The influence of exogenous hormones on the cancer pathogenesis and development is a subject of ceaseless studies and observations. However incomplete statistical and epidemiological data hamper deducing about the risk of cancer among these people. The article describes a case of a transgender female-to-male (FtM) patient during gender transition with two primary neoplasms (endometrial cancer and colon cancer) as well as Lynch syndrome and von Recklinghausen’s disease confirmed by next-generation sequencing (NGS). 

Abstract

Transgender is defined as an incongruence between the assigned at birth sex and an experienced gender identity. The biological sex is neither familiar nor acceptable to transgender people. Gender-affirming hormone treatment (GHT) is a multidisciplinary approach aiming to develop and maintain physical characteristics of the desirable sex. The influence of exogenous hormones on the cancer pathogenesis and development is a subject of ceaseless studies and observations. However incomplete statistical and epidemiological data hamper deducing about the risk of cancer among these people. The article describes a case of a transgender female-to-male (FtM) patient during gender transition with two primary neoplasms (endometrial cancer and colon cancer) as well as Lynch syndrome and von Recklinghausen’s disease confirmed by next-generation sequencing (NGS). 

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Keywords

transgender; transgender man; cross-sex hormone therapy; Lynch syndrome; von Recklinghausen disease; colon cancer; endometrial cancer

About this article
Title

Genetically burdened transgender man during gender reassignment process with two primary neoplasms: a case report

Journal

Oncology in Clinical Practice

Issue

Ahead of print

Article type

Case report

Published online

2021-04-07

DOI

10.5603/OCP.2021.0009

Keywords

transgender
transgender man
cross-sex hormone therapy
Lynch syndrome
von Recklinghausen disease
colon cancer
endometrial cancer

Authors

Agnieszka Bobola
Anita Gorzelak-Magiera
Katarzyna Steinhof-Radwańska
Andrzej Lorek
Michał Kliber
Iwona Gisterek

References (18)
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