Vol 16, No 4 (2020)
Review paper
Published online: 2020-08-17

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Neratinib in extended adjuvant therapy for HER2-positive early breast cancer

Tomasz Kubiatowski1
Oncol Clin Pract 2020;16(4):201-205.


HER2 overexpression is found in approximately 20% of patients with breast cancer and is associated with an unfavorable prognosis. The use of chemotherapy and targeted therapies blocking HER2 function in patients with early HER2 positive breast cancer has led to significant clinical benefits. Despite this, approximately 25% of patients initially treated with trastuzumab experience recurrence of invasive disease within 5 years of completion of adjuvant treatment. Neratinib is an oral, irreversible, small molecule tyrosine kinase inhibitor blocking the intracellular domain of the HER1, HER2 and HER4 receptor, whose activity in extended anti-HER2 adjuvant treatment in HER2-positive early breast cancer patients has been confirmed in ExteNET trial. It has been shown that the use of extended therapy with neratinib after adjuvant trastuzumab treatment in patients with early HER2-positive breast cancer led to a 33% reduction in the risk of invasive disease recurring, with a greater effect observed in ER/PgR positive patients and those with involvement 4 and more lymph nodes.

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