Vol 15, No 6 (2019)
Review paper
Published online: 2020-01-10
Molecular subtypes of colorectal cancer as a potential prognostic and predictive factor in the selection of the optimal treatment strategy
Oncol Clin Pract 2019;15(6):320-325.
Abstract
Colorectal cancer is one of the most common cancers and is the third cause of death from malignant tumours. In recent years, a consensus has been developed that distinguishes four subtypes of colon cancer (CMS, consensus molecular subtypes): CMS1 — immunological, CMS2 — canonical, CMS3 — metabolic, and CMS4 — mesenchymal. They differ in terms of clinical course and response to chemotherapy and biological treatment. The practical application of molecular classification can be helpful as a prognostic and predictive factor in the selection of an optimal and individualised strategy for the treatment of individual patients.
Keywords: colon cancerCMSchemotherapymolecular-targeted treatment
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