open access
Vol 14, No 5 (2018)
Review paper
Published online: 2019-02-15
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Systemic treatments for advanced cutaneous melanoma — Cochrane Systematic Review 2018
Joanna Połowinczak-Przybyłek, Piotr Potemski
DOI: 10.5603/OCP.2018.0030
·
Oncol Clin Pract 2018;14(5):241-248.
open access
Vol 14, No 5 (2018)
REVIEW ARTICLES
Published online: 2019-02-15
Abstract
The results of the systematic review have the leading place in the hierarchy of clinical data reliability. They allow to extend the conclusions from individual studies to a larger population, minimizing the risk of systematic errors. Meta-analysis is the final step of the review of enough homogenous primary research that allow to quantitatively synthesize their results. In 2018, the Cochrane systematic review and data meta-analysis which assessed the effects of various systemic treatments of metastatic cutaneous melanoma were published. All relevant trials published up to October 2017 were included. This article introduces the assumptions of the meta-analysis and presents its results regarding the effectiveness of the most important systemic treatments of melanoma.
Abstract
The results of the systematic review have the leading place in the hierarchy of clinical data reliability. They allow to extend the conclusions from individual studies to a larger population, minimizing the risk of systematic errors. Meta-analysis is the final step of the review of enough homogenous primary research that allow to quantitatively synthesize their results. In 2018, the Cochrane systematic review and data meta-analysis which assessed the effects of various systemic treatments of metastatic cutaneous melanoma were published. All relevant trials published up to October 2017 were included. This article introduces the assumptions of the meta-analysis and presents its results regarding the effectiveness of the most important systemic treatments of melanoma.
Get Citation
Keywords
Cochrane meta-analysis; metastatic melanoma; anti-BRAF/anti-MEK therapy; immunotherapy
About this articleTitle
Systemic treatments for advanced cutaneous melanoma — Cochrane Systematic Review 2018
Journal
Issue
Article type
Review paper
Pages
241-248
Published online
2019-02-15
DOI
10.5603/OCP.2018.0030
Bibliographic record
Oncol Clin Pract 2018;14(5):241-248.
Keywords
Cochrane meta-analysis
metastatic melanoma
anti-BRAF/anti-MEK therapy
immunotherapy
Authors
Joanna Połowinczak-Przybyłek
Piotr Potemski
References (20)- Polski Instytut Evidence Based Medicine. http://ebm.org.pl/show.php?aid=15739&_tc=272C56A7C6FEB3D89BA5503840A57516 (dostęp z dnia 22.07.2018.).
- http://poland.cochrane.org/pl/jak-interpretować-przeglądy-systematyczne (dostęp z dnia 22.07.2018.).
- Bała M, Leśniak W, Jaeschke R. Proces przygotowywania przeglądów systematycznych, z uwzględnieniem przeglądów Cochrane. Polish Archives of Internal Medicine. 2015; 125(Special Issue): 16–25.
- Leśniak W, Bała M, Jaeschke R, et al. Od danych naukowych do praktycznych zaleceń – tworzenie wytycznych według metodologii GRADE. Polish Archives of Internal Medicine. 2015; 125(Special Issue): 26–41.
- https://poland.cochrane.org/pl/cochrane (dostęp z dnia 22.07.2018).
- Pasquali S, Hadjinicolaou AV, Chiarion Sileni V, et al. Systemic treatments for metastatic cutaneous melanoma. Cochrane Database Syst Rev. 2018; 2: CD011123.
- Robert C, Thomas L, Bondarenko I, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011; 364(26): 2517–2526.
- Ribas A, Kefford R, Marshall MA, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol. 2013; 31(5): 616–622.
- Robert C, Long GV, Brady B, et al. Nivolumab in previously untreated melanoma without BRAF mutation. N Engl J Med. 2015; 372(4): 320–330.
- Larkin J, Chiarion-Sileni V, Gonzalez R, et al. Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma. N Engl J Med. 2015; 373(1): 23–34.
- Hauschild A, Grob JJ, Demidov LV, et al. Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet. 2012; 380(9839): 358–365.
- McArthur GA, Chapman PB, Robert C, et al. Safety and efficacy of vemurafenib in BRAF(V600E) and BRAF(V600K) mutation-positive melanoma (BRIM-3): extended follow-up of a phase 3, randomised, open-label study. Lancet Oncol. 2014; 15(3): 323–332.
- Gupta A, Love S, Schuh A, et al. DOC-MEK: a double-blind randomized phase II trial of docetaxel with or without selumetinib in wild-type BRAF advanced melanoma. Ann Oncol. 2014; 25(5): 968–974.
- Flaherty KT, Robert C, Hersey P, et al. METRIC Study Group. Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med. 2012; 367(2): 107–114.
- Robert C, Dummer R, Gutzmer R, et al. Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study. The Lancet Oncology. 2013; 14(8): 733–740.
- Robert C, Karaszewska B, Schachter J, et al. Improved overall survival in melanoma with combined dabrafenib and trametinib. N Engl J Med. 2015; 372(1): 30–39.
- Long GV, Stroyakovskiy D, Gogas H, et al. Dabrafenib and trametinib versus dabrafenib and placebo for Val600 BRAF-mutant melanoma: a multicentre, double-blind, phase 3 randomised controlled trial. Lancet. 2015; 386(9992): 444–451.
- Larkin J, Ascierto PA, Dréno B, et al. Combined vemurafenib and cobimetinib in BRAF-mutated melanoma. N Engl J Med. 2014; 371(20): 1867–1876.
- Flaherty KT, Infante JR, Daud A, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med. 2012; 367(18): 1694–1703.
- Połowinczak-Przybyłek J, Potemski P. Treatment of patients with advanced melanoma harboring the BRAF V600 mutation. Oncol Clin Pract. 2018; 14: 48–52.