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Published online: 2024-01-24

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Dendritic cell immunotherapy and topotecan-based metronomic chemotherapy in ovarian cancer — a case study and literature review

Patrycja Mrowczyk1, Maria Rozpłoch-Sapa1, Paweł M. Potocki2

Abstract

Advanced ovarian cancer is associated with an unsatisfactory prognosis. Systemic treatment toxicities adversely affect patient quality of life. Therefore, new, better therapies are needed. We present a case of a patient treated for recurrent ovarian cancer with a sequence of experimental cellular immunotherapy and chemotherapy in both classical and metronomic dosing with satisfactory results. A brief literature review on the subject of metronomic chemotherapy and immunotherapy in ovarian cancer is also provided. The addition of a dendritic vaccine to standard chemotherapy may be a valuable therapeutic option in the group of patients with platinum-sensitive recurrent ovarian cancer. Metronomic chemotherapy is not adequately researched in this setting although it appears to be a noteworthy alternative to classically dosed chemotherapy.

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