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Published online: 2023-12-18

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Immunochemotherapy in patients with non-squamous lung cancer

Adam Płużański1, Aleksandra Piórek1


Immunochemotherapy is one of the main treatment options in patients with non-squamous non-small-cell lung cancer without molecular targeted abnormalities. In Poland, immunotherapy given concurrently with chemotherapy is available in patients with programmed death ligand 1 (PD-L1) expression below 50%. Pembrolizumab plus chemotherapy and nivolumab with ipilimumab with 2 cycles of chemotherapy are more efficient than chemotherapy alone with longer progression-free survival (PFS) and overall survival (OS). Other immunochemotherapy regimens including atezolizumab, durvalumab, tremelimumab, or cemiplimab are not used in daily practice in Poland. Benefits observed with immunochemotherapy are limited to patients in Eastern Cooperative Oncology Group (ECOG) performance status of 0–1 and without contraindications to immune checkpoint inhibitors and cytotoxic agents. 

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