Cardiac metastasis of lung cancer diagnosed by fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)
Abstract
Lung cancer is currently one of the most common malignancies worldwide. Among all metastatic sites of this cancer, cardiac metastases are exceptional, and long-term prognosis in these patients is very poor. 18F-FDG PET/CT is a valuable imaging tool for initial staging and assessment of treatment response of various neoplasms. In the case of lung cancer, its role is clearly defined, and its effectiveness is superior to other diagnostic imaging methods. We present a rare 18F-FDG PET/CT image finding in a 71-year-old man with biopsy-proven lung squamous cell carcinoma, showing increased cardiac 18F-FDG uptake subsequently found to be compatible cardiac metastasis.
Keywords: cardiac metastasisFDGlung cancerPET/CT
References
- Riihimäki M, Hemminki A, Sundquist K, et al. The epidemiology of metastases in neuroendocrine tumors. Int J Cancer. 2016; 139(12): 2679–2686.
- Paraskevaidis IA, Michalakeas CA, Papadopoulos CH, et al. Cardiac tumors. ISRN Oncol. 2011; 2011: 208929.
- Bussani R, De-Giorgio F, Abbate A, et al. Cardiac metastases. J Clin Pathol. 2007; 60(1): 27–34.
- Murad R, Bakkar R, Sukkar R, et al. A Case of Ewing Sarcoma Presenting With Cardiac Metastasis. World J Pediatr Congenit Heart Surg. 2019; 10(5): 632–634.
- Reynen K, Köckeritz U, Strasser RH. Metastases to the heart. Ann Oncol. 2004; 15(3): 375–381.
- Shehata BM, Thomas JE, Doudenko-Rufforny I. Metastatic carcinoid to the conducting system-is it a rare or merely unrecognized manifestation of carcinoid cardiopathy? Arch Pathol Lab Med. 2002; 126(12): 1538–1540.
- Lahmidi I, Assoweh CD, Haddiya I, et al. Clinicopathological features of adult right-sided cardiac masses: Analysis of 19 cases. Ann Med Surg (Lond). 2022; 77: 103613.
- Das A, Das SK, Pandit S, et al. Bronchogenic Carcinoma with Cardiac Invasion Simulating Acute Myocardial Infarction. Case Rep Oncol Med. 2016; 2016: 7813509.
- Ito T, Ishikawa N, Negishi T, et al. Cardiac metastasis of tongue cancer may cause sudden death. Auris Nasus Larynx. 2008; 35(3): 423–425.
- Lyon AR, López-Fernández T, Couch LS, et al. ESC Scientific Document Group. 2022 ESC Guidelines on cardio-oncology developed in collaboration with the European Hematology Association (EHA), the European Society for Therapeutic Radiology and Oncology (ESTRO) and the International Cardio-Oncology Society (IC-OS). Eur Heart J. 2022; 43(41): 4229–4361.
- Burazor I, Aviel-Ronen S, Imazio M, et al. Metastatic cardiac tumors: from clinical presentation through diagnosis to treatment. BMC Cancer. 2018; 18(1): 202.
- Bogren HG, DeMaria AN, Mason DT. Imaging procedures in the detection of cardiac tumors, with emphasis on echocardiography: a review. Cardiovasc Intervent Radiol. 1980; 3(3): 107–125.
- Yin H, Mao W, Tan H, et al. Role of F-FDG PET/CT imaging in cardiac and pericardial masses. J Nucl Cardiol. 2022; 29(3): 1293–1303.
- Dos Santos VM, Dos Santos LA. Cardiac and lymphatic metastases from lung cancer. Arch Iran Med. 2018; 21(2): 82–83.
- Tyebally S, Chen D, Bhattacharyya S, et al. Cardiac Tumors: State-of-the-Art Review. JACC CardioOncol. 2020; 2(2): 293–311.
- Chen TWW, Loong HH, Srikanthan A, et al. Primary cardiac sarcomas: A multi-national retrospective review. Cancer Med. 2019; 8(1): 104–110.
- Jumeau R, Vincenti MG, Pruvot E, et al. Curative management of a cardiac metastasis from lung cancer revealed by an electrical storm. Clin Transl Radiat Oncol. 2020; 21: 62–65.
- Bussani R, Castrichini M, Restivo L, et al. Cardiac Tumors: Diagnosis, Prognosis, and Treatment. Curr Cardiol Rep. 2020; 22(12): 169.