open access

Vol 1, No 1 (2005)
Review paper
Published online: 2005-05-17
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Progress in systemic therapy of advanced colorectal cancer

Maciej Krzakowski
Onkol. Prak. Klin 2005;1(1):27-39.

open access

Vol 1, No 1 (2005)
REVIEW ARTICLES
Published online: 2005-05-17

Abstract

Until the early 1990s the therapeutic options of systemic therapy for advanced colorectal cancer were limited to fluorouracil and produced rather disappointing results. The progress in the management of this disease has been very rapid during the last decade. The median duration of survival among patients with advanced colorectal cancer has almost doubled from 10–12 months to 18–20 months. This improvement has been achieved due to the introduction of several new cytotoxic agents as well as the entirely new category of treatment addressing molecular targets. Although some of these new therapeutic modalities are still experimental, they may herald a shift in the management of colorectal cancer in very near future. The incorporation of novel therapeutic options into standard care should be based on mature data from well-projected clinical trials. Physicians should be aware of new toxicity profiles of modern therapies as well as their financial consequences.

Abstract

Until the early 1990s the therapeutic options of systemic therapy for advanced colorectal cancer were limited to fluorouracil and produced rather disappointing results. The progress in the management of this disease has been very rapid during the last decade. The median duration of survival among patients with advanced colorectal cancer has almost doubled from 10–12 months to 18–20 months. This improvement has been achieved due to the introduction of several new cytotoxic agents as well as the entirely new category of treatment addressing molecular targets. Although some of these new therapeutic modalities are still experimental, they may herald a shift in the management of colorectal cancer in very near future. The incorporation of novel therapeutic options into standard care should be based on mature data from well-projected clinical trials. Physicians should be aware of new toxicity profiles of modern therapies as well as their financial consequences.
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Keywords

colorectal cancer; advanced stage; systemic therapy; chemotherapy; targeted therapy

About this article
Title

Progress in systemic therapy of advanced colorectal cancer

Journal

Oncology in Clinical Practice

Issue

Vol 1, No 1 (2005)

Article type

Review paper

Pages

27-39

Published online

2005-05-17

Bibliographic record

Onkol. Prak. Klin 2005;1(1):27-39.

Keywords

colorectal cancer
advanced stage
systemic therapy
chemotherapy
targeted therapy

Authors

Maciej Krzakowski

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