open access

Vol 1, No 1 (2005)
Review paper
Published online: 2005-05-17
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DNA microarray studies on breast cancer

Radzisław Kordek, Andrzej K. Bednarek
Onkol. Prak. Klin 2005;1(1):10-17.

open access

Vol 1, No 1 (2005)
REVIEW ARTICLES
Published online: 2005-05-17

Abstract

Molecular studies based on the analysys of a alterations in single or in a few genes did not produce results, which may be used as an important individual prognostic factor. It shows, that as cancer is not a result of a single gene alteration, we need to study a multiple gene alterations, and not only on the structural level but also analyzing its expression. As so many genes are involved in different cellular controlling mechanisms, the only way to make tumor profiling and looking for its biological significance is concerted analysis of thousands genes simultaneously. Such a gene expression profiling on a big scale is now possible with cDNA microarray technology.
Patients with breast cancer with the same histology and the same clinical stage often present different clinical outcome. Adjuvant therapy is ordered mostly on the basis of these standard prognostic factors, but 70–80% of patient receiving this therapy, would have survived without it. The recent development of gene expression microarray provides an opportunity to prepare more detailed profiling of tumors, alowing to treat only those patients who are most likely to have a benefit from this.

Abstract

Molecular studies based on the analysys of a alterations in single or in a few genes did not produce results, which may be used as an important individual prognostic factor. It shows, that as cancer is not a result of a single gene alteration, we need to study a multiple gene alterations, and not only on the structural level but also analyzing its expression. As so many genes are involved in different cellular controlling mechanisms, the only way to make tumor profiling and looking for its biological significance is concerted analysis of thousands genes simultaneously. Such a gene expression profiling on a big scale is now possible with cDNA microarray technology.
Patients with breast cancer with the same histology and the same clinical stage often present different clinical outcome. Adjuvant therapy is ordered mostly on the basis of these standard prognostic factors, but 70–80% of patient receiving this therapy, would have survived without it. The recent development of gene expression microarray provides an opportunity to prepare more detailed profiling of tumors, alowing to treat only those patients who are most likely to have a benefit from this.
Get Citation

Keywords

microarrays; breast cancer; prognosis; molecular profiles

About this article
Title

DNA microarray studies on breast cancer

Journal

Oncology in Clinical Practice

Issue

Vol 1, No 1 (2005)

Article type

Review paper

Pages

10-17

Published online

2005-05-17

Bibliographic record

Onkol. Prak. Klin 2005;1(1):10-17.

Keywords

microarrays
breast cancer
prognosis
molecular profiles

Authors

Radzisław Kordek
Andrzej K. Bednarek

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