Advances in biology and treatment of Hodgkin lymphoma

Abstract

In this paper, the characteristic features of biology and clinical aspects of Hodgkin lymphoma (HL) are updated and reviewed. The first part is focused on the ontogenesis of Reed-Sternberg (R-S) and Hodgkin (H) cells as well as mechanisms involved in their malignant transformation. The clinical part of the review concerns the histopathological classification of HL, prognostic factors’ role in therapy decision-making process, and current recommendations for choosing the first line treatment of HL.