open access

Vol 1, No 2 (2005)
Review paper
Published online: 2005-06-08
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Prognostic significance of cyclin E in breast cancer

Piotr Potemski, Radzisław Kordek
Onkol. Prak. Klin 2005;1(2):76-82.

open access

Vol 1, No 2 (2005)
REVIEW ARTICLES
Published online: 2005-06-08

Abstract

In the present review the role of cyclin E and other cell cycle molecules as prognostic markers in breast cancer is discussed. Cell cycle transitions are controlled by cyclin-dependent protein kinases. Cyclin E is an important regulator of cell cycle progression from phase G1 to synthetic phase. The highest concentration of cyclin E in the cell is observed near restriction point in the late G1 phase. In breast cancer the aberrant expression of cyclin E has been frequently described. In breast cancer cells fulllenght cyclin E is degradated by proteolysis to its low molecular weight isoforms. Overexpression of both cyclin E and low molecular weight isoforms gives tumor cells growth advantage. Expression of cyclin E and other cell cycle molecules can be evaluated by immunohistochemistry, tissue microarrays, various blot assays, reverse transcription-polymerase chain reaction and DNA microarrays.
The results of numerous studies show that overexpression of cyclin E may be an important prognostic factor. However, in some models of multivariate analysis this effect was eliminated by estrogen receptors presence or other classical prognostic factors.
However, futher confirmatory studies are warranted as overexpression of cyclin E may also be just a part of gene profile and not a single, independent prognostic factor.

Abstract

In the present review the role of cyclin E and other cell cycle molecules as prognostic markers in breast cancer is discussed. Cell cycle transitions are controlled by cyclin-dependent protein kinases. Cyclin E is an important regulator of cell cycle progression from phase G1 to synthetic phase. The highest concentration of cyclin E in the cell is observed near restriction point in the late G1 phase. In breast cancer the aberrant expression of cyclin E has been frequently described. In breast cancer cells fulllenght cyclin E is degradated by proteolysis to its low molecular weight isoforms. Overexpression of both cyclin E and low molecular weight isoforms gives tumor cells growth advantage. Expression of cyclin E and other cell cycle molecules can be evaluated by immunohistochemistry, tissue microarrays, various blot assays, reverse transcription-polymerase chain reaction and DNA microarrays.
The results of numerous studies show that overexpression of cyclin E may be an important prognostic factor. However, in some models of multivariate analysis this effect was eliminated by estrogen receptors presence or other classical prognostic factors.
However, futher confirmatory studies are warranted as overexpression of cyclin E may also be just a part of gene profile and not a single, independent prognostic factor.
Get Citation

Keywords

breast cancer; prognostic factors; cyclin E; review

About this article
Title

Prognostic significance of cyclin E in breast cancer

Journal

Oncology in Clinical Practice

Issue

Vol 1, No 2 (2005)

Article type

Review paper

Pages

76-82

Published online

2005-06-08

Bibliographic record

Onkol. Prak. Klin 2005;1(2):76-82.

Keywords

breast cancer
prognostic factors
cyclin E
review

Authors

Piotr Potemski
Radzisław Kordek

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