open access

Vol 2, No 4 (2006)
Case report
Published online: 2006-09-26
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Palliative chemotherapy with kapecytabine and gemcytabine in patients with advenced gallbladder cancer

Andrzej Kaiser, Marcin Wolski, Krzysztof Forgacz
Onkol. Prak. Klin 2006;2(4):174-180.

open access

Vol 2, No 4 (2006)
CASE REPORTS
Published online: 2006-09-26

Abstract

Palliative chemotherapy was attempted in 4 patients with advanced gallbladder carcinoma (stage III or IV).The possibility of surgical treatment was excluded at all patients. Chemotherapy regimen GX included capecitabine (orally in the daily dose of 2500 mg/m2 day 1 to 14) and gemcitabine (intravenously in the dose 1000 mg/m2 day 1 and 8; repeated every 21 days). Normalization or significant reduction of initially elevated liver function tests (transaminases and bilirubin) and serum markers (CEA and CA 19.9) as well as symptom improvement or disapearance were found in all patients. These findings justify prospective study evaluating capecitabine- and gemcitabine-containing chemotherapy with regard of its impact on survival rates in patients with advanced gallbladder carcinoma.

Abstract

Palliative chemotherapy was attempted in 4 patients with advanced gallbladder carcinoma (stage III or IV).The possibility of surgical treatment was excluded at all patients. Chemotherapy regimen GX included capecitabine (orally in the daily dose of 2500 mg/m2 day 1 to 14) and gemcitabine (intravenously in the dose 1000 mg/m2 day 1 and 8; repeated every 21 days). Normalization or significant reduction of initially elevated liver function tests (transaminases and bilirubin) and serum markers (CEA and CA 19.9) as well as symptom improvement or disapearance were found in all patients. These findings justify prospective study evaluating capecitabine- and gemcitabine-containing chemotherapy with regard of its impact on survival rates in patients with advanced gallbladder carcinoma.
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Keywords

advanced gallbladder carcinoma; chemotherapy; capecitabine; gemcitabine

About this article
Title

Palliative chemotherapy with kapecytabine and gemcytabine in patients with advenced gallbladder cancer

Journal

Oncology in Clinical Practice

Issue

Vol 2, No 4 (2006)

Article type

Case report

Pages

174-180

Published online

2006-09-26

Bibliographic record

Onkol. Prak. Klin 2006;2(4):174-180.

Keywords

advanced gallbladder carcinoma
chemotherapy
capecitabine
gemcitabine

Authors

Andrzej Kaiser
Marcin Wolski
Krzysztof Forgacz

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