Vol 2, No 4 (2006)
Case report
Published online: 2006-09-26
Palliative chemotherapy with kapecytabine and gemcytabine in patients with advenced gallbladder cancer
Onkol. Prak. Klin 2006;2(4):174-180.
Abstract
Palliative chemotherapy was attempted in 4 patients with advanced gallbladder carcinoma (stage III or
IV).The possibility of surgical treatment was excluded at all patients. Chemotherapy regimen GX included
capecitabine (orally in the daily dose of 2500 mg/m2 day 1 to 14) and gemcitabine (intravenously in the
dose 1000 mg/m2 day 1 and 8; repeated every 21 days). Normalization or significant reduction of initially
elevated liver function tests (transaminases and bilirubin) and serum markers (CEA and CA 19.9) as well
as symptom improvement or disapearance were found in all patients. These findings justify prospective
study evaluating capecitabine- and gemcitabine-containing chemotherapy with regard of its impact on survival rates in patients with advanced gallbladder carcinoma.
Keywords: advanced gallbladder carcinomachemotherapycapecitabinegemcitabine