Breast cancer therapy in elderly

Abstract

Currently, almost 50% of all breast cancer occur in women older than 65 years of age. In comparison to younger women, mortality in elderly patients is higher. The situation may be explained by late diagnosis, comorbidities which significantly limit treatment options, but also non-cancer specific morbidity and mortality. It has been observed that elderly women are often treated suboptimally, even if radical treatment is indicated. Results of clinical and observational studies provide convincing evidence that older patient may benefit from antineoplastic therapy. While discussing possible treatment options, it seems reasonable to consider individually assessed risk of adverse effects, magnitude of benefits with regard to life expectancy and patient’s preferences.