open access

Vol 3, No 1 (2007)
Review paper
Published online: 2007-01-12
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New options in systemic adjuvant therapy of breast cancer

Maciej Krzakowski
Onkol. Prak. Klin 2007;3(1):8-15.

open access

Vol 3, No 1 (2007)
REVIEW ARTICLES
Published online: 2007-01-12

Abstract

Significant survival benefits derived from the use of adjuvant systemic therapy in early breast cancer were progressively defined over the last years. Current practice guidelines recommend an important change in selection of adjuvant systemic therapy with priority to endocrine treatment. However, cytotoxic adjuvant therapy remains an only option for endocrine non-responsive patients and is also recommended in numerous clinical situations for endocrine responsive breast cancer. Reports from several randomised trials justified the use of taxoids within adjuvant chemotherapy. Finally, four trials demonstrated the substantial contribution of trastuzumab in appropriately defined patients. This review focuses on the use of taxoids and trastuzumab in adjuvant systemic therapy of early breast cancer.

Abstract

Significant survival benefits derived from the use of adjuvant systemic therapy in early breast cancer were progressively defined over the last years. Current practice guidelines recommend an important change in selection of adjuvant systemic therapy with priority to endocrine treatment. However, cytotoxic adjuvant therapy remains an only option for endocrine non-responsive patients and is also recommended in numerous clinical situations for endocrine responsive breast cancer. Reports from several randomised trials justified the use of taxoids within adjuvant chemotherapy. Finally, four trials demonstrated the substantial contribution of trastuzumab in appropriately defined patients. This review focuses on the use of taxoids and trastuzumab in adjuvant systemic therapy of early breast cancer.
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Keywords

breast cancer; adjuvant therapy; chemotherapy; taxoids; trastuzumab

About this article
Title

New options in systemic adjuvant therapy of breast cancer

Journal

Oncology in Clinical Practice

Issue

Vol 3, No 1 (2007)

Article type

Review paper

Pages

8-15

Published online

2007-01-12

Bibliographic record

Onkol. Prak. Klin 2007;3(1):8-15.

Keywords

breast cancer
adjuvant therapy
chemotherapy
taxoids
trastuzumab

Authors

Maciej Krzakowski

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