Advances in diagnosis and treatment of plasmocytoma

Abstract

Plasmocytoma (multiple myeloma) is characterised by monoclonal proliferation of plasma cells which are producing monoclonal immunoglobulin (M protein). Plasma cell tumor occurrence gives it the second place among hematological tumors. The disease develops in many stages. In the first stage the cells B becomes immortal due to chromosomes translocation in the immunoglobuline heavy chain locus. The time from the first incident to symptomatic disease lasts long and takes 20-30 years, so the average age of multiple myeloma detection is 65.
The most important risk factors are the levels of beta2 microglobulines and albumines, on which the prognostic classification is based.