open access

Vol 3, No 2 (2007)
Review paper
Published online: 2007-03-14
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Indications for high dose chemothin malignant neoplasmserapy supported by autologous hematopoietic cell transplantation in malignant neoplasms

Renata Zaucha, Jan Maciej Zaucha, Jan Walewski, Jacek Jassem
Onkol. Prak. Klin 2007;3(2):59-69.

open access

Vol 3, No 2 (2007)
REVIEW ARTICLES
Published online: 2007-03-14

Abstract

High dose chemotherapy supported by autologous hematopoietic cell transplantation (auto-HCT) remains the accepted treatment option for lymphomas and some solid tumors, particularly in relapse, resistance to standard treatment and sometimes as a consolidation of first remission in case of unfavorable prognostic factors at diagnosis. The results of recently published clinical trials as well as introduction of new agents, such as monoclonal antibodies (anti-CD20) free or conjugated with radioisotopes in form of radioimmunotherapy (RIT), thalidomide and its analogs, and proteasome inhibitors (bortezomib) create a necessity to define again the role of auto-HCT in the treatment of these malignancies. The paper reviews a postulated curative mechanism of auto-HCT, transplant-related acute and late complications and discusses the current indications for auto-HCT in the treatment of lymphomas and solid tumors in adults.

Abstract

High dose chemotherapy supported by autologous hematopoietic cell transplantation (auto-HCT) remains the accepted treatment option for lymphomas and some solid tumors, particularly in relapse, resistance to standard treatment and sometimes as a consolidation of first remission in case of unfavorable prognostic factors at diagnosis. The results of recently published clinical trials as well as introduction of new agents, such as monoclonal antibodies (anti-CD20) free or conjugated with radioisotopes in form of radioimmunotherapy (RIT), thalidomide and its analogs, and proteasome inhibitors (bortezomib) create a necessity to define again the role of auto-HCT in the treatment of these malignancies. The paper reviews a postulated curative mechanism of auto-HCT, transplant-related acute and late complications and discusses the current indications for auto-HCT in the treatment of lymphomas and solid tumors in adults.
Get Citation

Keywords

autologous hematopoietic cell transplantation; lymphoma; multiple myeloma; malignant neoplasms

About this article
Title

Indications for high dose chemothin malignant neoplasmserapy supported by autologous hematopoietic cell transplantation in malignant neoplasms

Journal

Oncology in Clinical Practice

Issue

Vol 3, No 2 (2007)

Article type

Review paper

Pages

59-69

Published online

2007-03-14

Bibliographic record

Onkol. Prak. Klin 2007;3(2):59-69.

Keywords

autologous hematopoietic cell transplantation
lymphoma
multiple myeloma
malignant neoplasms

Authors

Renata Zaucha
Jan Maciej Zaucha
Jan Walewski
Jacek Jassem

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