open access

Vol 3, No 4 (2007)
Review paper
Published online: 2007-07-27
Get Citation

Chemoradiotherapy and molecular targeted therapy - options and perspective of treatment of patients with squamous cell head and neck cancer

Andrzej Kawecki
Onkol. Prak. Klin 2007;3(4):169-176.

open access

Vol 3, No 4 (2007)
REVIEW ARTICLES
Published online: 2007-07-27

Abstract

Results of treatment with surgery and/or radiotherapy for locally advanced squamous cell head and neck cancer are still unsatisfactory. During last decade concomitant chemoradiotherapy became a new standard in this group of patients. Concomitant chemoradiation in comparison to radiotherapy produce singificant benefit of survival and also is valuable as an organ preservation treatment. However, acute and late toxicity of this method is high and real therapeutic gain is obtained by limited group of patients. Intensive clinical investigations on novel therapeutic strategies are in progress. The first direction of trials is combination of induction chemotherapy and concomitant chemoradiotherapy. The second very attractive strategy is using molecular targeted therapy with radiation alone or chemoradiotherapy. Results of recent clinical trials and perspective of novel treatment strategies were discussed.

Abstract

Results of treatment with surgery and/or radiotherapy for locally advanced squamous cell head and neck cancer are still unsatisfactory. During last decade concomitant chemoradiotherapy became a new standard in this group of patients. Concomitant chemoradiation in comparison to radiotherapy produce singificant benefit of survival and also is valuable as an organ preservation treatment. However, acute and late toxicity of this method is high and real therapeutic gain is obtained by limited group of patients. Intensive clinical investigations on novel therapeutic strategies are in progress. The first direction of trials is combination of induction chemotherapy and concomitant chemoradiotherapy. The second very attractive strategy is using molecular targeted therapy with radiation alone or chemoradiotherapy. Results of recent clinical trials and perspective of novel treatment strategies were discussed.
Get Citation

Keywords

squamous cell head and neck cancer; concomitant chemoradiotherapy; neoadjuvant chemotherapy; molecular targeted therapy

About this article
Title

Chemoradiotherapy and molecular targeted therapy - options and perspective of treatment of patients with squamous cell head and neck cancer

Journal

Oncology in Clinical Practice

Issue

Vol 3, No 4 (2007)

Article type

Review paper

Pages

169-176

Published online

2007-07-27

Bibliographic record

Onkol. Prak. Klin 2007;3(4):169-176.

Keywords

squamous cell head and neck cancer
concomitant chemoradiotherapy
neoadjuvant chemotherapy
molecular targeted therapy

Authors

Andrzej Kawecki

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl