Contemporary systemic preoperative treatment of breast cancer - chemotherapy

Abstract

Preoperative systemic treatment proved benefit in treatment of locally advanced breast cancer, yet no regimen is recommended as treatment of choice. No clinical benefit was found for neoadjuvant versus adjuvant setting in terms of progression-free and overall survival for operable breast cancer. The only benefit is a possibility of breast conserving treatment, but multidisciplinary approach is mandatory in these cases. For this report the author reviewed the literature to determine most beneficial preoperative systemic treatment regimens and identify patients who are likely to respond to specific agents by finding response predictors.