Vol 4, No 4 (2008)
Case report
Published online: 2008-10-08
Merkel cell carcinoma - neuroendocrine carcinoma of the skin, treatment
Onkol. Prak. Klin 2008;4(4):141-144.
Abstract
Merkel cell carcinoma (MCC) is a very rare form of the skin cancer with an aggressive biological behavior.
The annual incidence is estimated to be 0.23 per 100,000 white population. Most cases occur in elderly
people, with the average age of presentation being 69 years. MCC occurs most commonly in areas of the
body that are exposed to the sun, with 50% occurring in the head and neck region and about 40% occurring
in the extremities. MCC typically appears as a red nodule with a shiny surface, often with overlying
telangiectasia. Regional nodes are involved in about 50% of the patients. Secondary sites of involvement
include the skin (28%), liver (13%), lung (10%), bone (10%), and brain (6%). Wide surgical excision of
tumor and regional lymph nodes with chemotherapy and radiotherapy is the treatment of choice and is
according to stage of disease. The following are recommendation based on early stage of disease, stage
IA and IB should be treated with surgical excision, in localization of head and neck with radiotherapy. Stage
II disease, requires excision followed by postoperative radiation to the primary site and for the nodal mass. The treatment intent in stage III disease is purely palliative and most often requires systemic chemotherapy.
Radiation can be used to palliate bony, brain secondary tumours, and to offer palliation with advanced
cutaneous deposits that are bleeding.
Keywords: Merkel- cell carcinomatreatmentradiotherapy