open access

Vol 4, No 5 (2008)
Review paper
Published online: 2008-10-10
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Statins in prevention and therapy of cancer

Piotr Mrówka, Eliza Głodkowska
Onkol. Prak. Klin 2008;4(5):177-191.

open access

Vol 4, No 5 (2008)
REVIEW ARTICLES
Published online: 2008-10-10

Abstract

Statins, inhibitors of one of the most important enzymes of cholesterol synthesis pathway - 3-hydroxy-3- -methyl-glutharyl-coenzyme-A (HMG-CoA), are commonly used as cholesterol level reducing drugs. Nowadays, more and more scientists take an interest of statins as potential both preventive and therapeutical anticancer agents. In vitro and in vivo experiments showed cytotoxic and cytostatic effect of statins in numerous cancer cell lines. Moreover, statins inhibit vascularisation in tumor and prevent metastasis. Optimistic pre-clinical tests results are not completely confirmed by clinical observations. Very promising results of clinical control trials showing a significant reduction of cancer risk in patients receiving statins were not confirmed in randomized clinical trials so far. Clinical trials concerning statins in anticancer therapy were not as successful as supposed. In this article we are trying to summarize current knowledge about potential statins usage in cancer prevention and treatment.

Abstract

Statins, inhibitors of one of the most important enzymes of cholesterol synthesis pathway - 3-hydroxy-3- -methyl-glutharyl-coenzyme-A (HMG-CoA), are commonly used as cholesterol level reducing drugs. Nowadays, more and more scientists take an interest of statins as potential both preventive and therapeutical anticancer agents. In vitro and in vivo experiments showed cytotoxic and cytostatic effect of statins in numerous cancer cell lines. Moreover, statins inhibit vascularisation in tumor and prevent metastasis. Optimistic pre-clinical tests results are not completely confirmed by clinical observations. Very promising results of clinical control trials showing a significant reduction of cancer risk in patients receiving statins were not confirmed in randomized clinical trials so far. Clinical trials concerning statins in anticancer therapy were not as successful as supposed. In this article we are trying to summarize current knowledge about potential statins usage in cancer prevention and treatment.
Get Citation

Keywords

statins; HMG-CoA reductase; apoptosis; metastasis; angiogenesis; cell cycle; tumor

About this article
Title

Statins in prevention and therapy of cancer

Journal

Oncology in Clinical Practice

Issue

Vol 4, No 5 (2008)

Article type

Review paper

Pages

177-191

Published online

2008-10-10

Bibliographic record

Onkol. Prak. Klin 2008;4(5):177-191.

Keywords

statins
HMG-CoA reductase
apoptosis
metastasis
angiogenesis
cell cycle
tumor

Authors

Piotr Mrówka
Eliza Głodkowska

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