Vol 4, No 5 (2008)
Review paper
Published online: 2008-10-10
Myeloma multiplex - new targets of treatment
Onkol. Prak. Klin 2008;4(5):172-176.
Abstract
Myeloma multiplex (plazmocytoma) is determinated by proliferation of atypical plasma cells. Microenvironment
of bone marrow and contact of myeloma and endothelial cells play an important role in myeloma
progression. Angiogenesis is a pathomofphological symptom of cancerogenesis and bone marrow stroma
promotes proliferation of myeloma cells, prevents their apoptosis and impedes cytostatics access
Keywords: multiple myelomatreatmentangiogenesis