open access

Vol 4, No 5 (2008)
Review paper
Published online: 2008-10-10
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Clinical aspects of diagnostics and systemic treatment of malignancies during pregnancy

Krzysztof Adamowicz, Elżbieta Goszczyńska-Matysiak, Joanna Adamowicz, Krystyna Serkies
Onkol. Prak. Klin 2008;4(5):165-171.

open access

Vol 4, No 5 (2008)
REVIEW ARTICLES
Published online: 2008-10-10

Abstract

The coincidence of malignant disease during pregnancy is uncommon. Today, the incidence of cancer in pregnancy has increased, due to the tendency to postpone childbirth to an older age. Making cancer therapy decision in pregnant women both disease and pregnancy advancement should be considered. In all cases fetal saving as well as mother’s fertility preservation are of great importance. Because of mutagenic effect the use of chemotherapy during the first trimester is contraindicated. Recently, increasing number of studies evaluated in selected pregnant women the use of chemotherapy after organogenesis, however the long-term consequences for children exposed to intra-uterine chemotherapy is not fully determined. The potential risks and benefits of such therapy still have to be cautiously weighted. Hormone therapy increases the risk of spontaneous abortion and during pregnancy is contraindicated. No sufficient data about the use of many form of targeted therapy for pregnant women with cancer are available so far.

Abstract

The coincidence of malignant disease during pregnancy is uncommon. Today, the incidence of cancer in pregnancy has increased, due to the tendency to postpone childbirth to an older age. Making cancer therapy decision in pregnant women both disease and pregnancy advancement should be considered. In all cases fetal saving as well as mother’s fertility preservation are of great importance. Because of mutagenic effect the use of chemotherapy during the first trimester is contraindicated. Recently, increasing number of studies evaluated in selected pregnant women the use of chemotherapy after organogenesis, however the long-term consequences for children exposed to intra-uterine chemotherapy is not fully determined. The potential risks and benefits of such therapy still have to be cautiously weighted. Hormone therapy increases the risk of spontaneous abortion and during pregnancy is contraindicated. No sufficient data about the use of many form of targeted therapy for pregnant women with cancer are available so far.
Get Citation

Keywords

pregnancy; chemotherapy; hormonal therapy; targeted therapy

About this article
Title

Clinical aspects of diagnostics and systemic treatment of malignancies during pregnancy

Journal

Oncology in Clinical Practice

Issue

Vol 4, No 5 (2008)

Article type

Review paper

Pages

165-171

Published online

2008-10-10

Bibliographic record

Onkol. Prak. Klin 2008;4(5):165-171.

Keywords

pregnancy
chemotherapy
hormonal therapy
targeted therapy

Authors

Krzysztof Adamowicz
Elżbieta Goszczyńska-Matysiak
Joanna Adamowicz
Krystyna Serkies

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