open access

Vol 4, No 6 (2008)
Case report
Published online: 2008-12-16
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Post-radiational ureteric fibrosis with extrarenal renal failure as a rare complication after adjuvant treatment of gastric cancer - a case report

Anna Świeboda-Sadlej, Marzanna Staszewska-Skurczyńska, Piyush Vyas, Ewa Żurawińska, Hubert Heleniak, Janusz Kocik, Anna Danek, Ewa Tragarz
Onkol. Prak. Klin 2008;4(6):219-222.

open access

Vol 4, No 6 (2008)
CASE REPORTS
Published online: 2008-12-16

Abstract

The principles of chemoradiotherapy for treating patients with radically resected gastric cancer are not fully established. In many oncological centres patients with unfavourable prognostic factors who previously had radical gastrectomy are treated with Macdonald regimen which includes combined fluorouracil with radiotherapy. Statistics indicate that more then 30% patients treated with chemoradiotherapy suffer from serious complication. In this article we describe a case of a patient who developed ureteric fibrosis with consequent renal failure as a rare life threatening complication of Macdonald regimen. The patient received chemoradiotherapy because of unfavourable prognostic factors and good performance status however he was in advanced age and with other comorbidities. These data support the notion of the high toxicity of this regimen and suggest that selection of patients for this treatment should be done very carefully. This is discussed in the context of other available therapies in gastric cancer.

Abstract

The principles of chemoradiotherapy for treating patients with radically resected gastric cancer are not fully established. In many oncological centres patients with unfavourable prognostic factors who previously had radical gastrectomy are treated with Macdonald regimen which includes combined fluorouracil with radiotherapy. Statistics indicate that more then 30% patients treated with chemoradiotherapy suffer from serious complication. In this article we describe a case of a patient who developed ureteric fibrosis with consequent renal failure as a rare life threatening complication of Macdonald regimen. The patient received chemoradiotherapy because of unfavourable prognostic factors and good performance status however he was in advanced age and with other comorbidities. These data support the notion of the high toxicity of this regimen and suggest that selection of patients for this treatment should be done very carefully. This is discussed in the context of other available therapies in gastric cancer.
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Keywords

gastric cancer; chemoradiotherapy; ureteric fibrosis

About this article
Title

Post-radiational ureteric fibrosis with extrarenal renal failure as a rare complication after adjuvant treatment of gastric cancer - a case report

Journal

Oncology in Clinical Practice

Issue

Vol 4, No 6 (2008)

Article type

Case report

Pages

219-222

Published online

2008-12-16

Bibliographic record

Onkol. Prak. Klin 2008;4(6):219-222.

Keywords

gastric cancer
chemoradiotherapy
ureteric fibrosis

Authors

Anna Świeboda-Sadlej
Marzanna Staszewska-Skurczyńska
Piyush Vyas
Ewa Żurawińska
Hubert Heleniak
Janusz Kocik
Anna Danek
Ewa Tragarz

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