Opportunities of combined treatment in metastatic colorectal cancer

Abstract

In majority of patients newly diagnosed colorectal cancer is advanced, in vast number of patients presents in metastatic phase. In last decade convenience of new, effective drugs improved expected survival in metastatic phase of disease. Clinical trials of last few years have shown that proficient combination of continuous, sequential systemic treatment with courageous metastases resection increases chance for long survival. In this article authors analyzed the newest reports from trials designed to answer the queries about indications to systemic and surgical treatment in palliative setting as well as intensity and sequence of combination of cytotoxic and targeted therapies. Owing to knowledge gained through these studies the aim of cure is possible instead of only delaying progression in late phase of the disease.