Antiangiogenic treatment of primary cancers of central nervous system

Abstract

High grade gliomas are among the most common primary brain tumors. They are highly vascularized structures and may serve as a perfect model to study the process of tumor angiogenesis and to investigate new anti-angiogenic therapies. This review focuses on the role of angiogenic factors in glioma development and presents new therapeutic strategies which interfere with angiogenesis.