Vol 6, No 1 (2010)
Case report
Published online: 2010-05-06
HER2 overexpressing advanced breast cancer - a case report
Onkol. Prak. Klin 2010;6(1):48-51.
Abstract
Despite the improvement in early detection and new therapeutic agents breast cancer remains the most
frequent cause of death among women with cancer in Poland. About 20% of patients have tumors overexpressing
HER2, which is associated with the higher risk of relapse and shorter overall survival. Introducing
to the therapy of metastatic breast cancer two molecularly targeted agents - trastuzumab and lapatinib
- significantly improved the results of the therapy in this subgroup of patients in metastatic setting. We are
presenting the case of a 44-years-old patient with metastatic breast cancer who was treated sequentially
with trastuzumab and lapatinib with long responses. This case also shows that reinduction of trastuzumab
after cardiac adverse event is possible and safe and is an example of an intrathecal therapy of carcinomatous
meningitis.
Keywords: breast canceroverexpression HER2trastuzumablapatinib
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