Vol 6, No 1 (2010)
Case report
Published online: 2010-05-06

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HER2 overexpressing advanced breast cancer - a case report

Roman Dubiański, Iwona Głogowska
Onkol. Prak. Klin 2010;6(1):48-51.


Despite the improvement in early detection and new therapeutic agents breast cancer remains the most frequent cause of death among women with cancer in Poland. About 20% of patients have tumors overexpressing HER2, which is associated with the higher risk of relapse and shorter overall survival. Introducing to the therapy of metastatic breast cancer two molecularly targeted agents - trastuzumab and lapatinib - significantly improved the results of the therapy in this subgroup of patients in metastatic setting. We are presenting the case of a 44-years-old patient with metastatic breast cancer who was treated sequentially with trastuzumab and lapatinib with long responses. This case also shows that reinduction of trastuzumab after cardiac adverse event is possible and safe and is an example of an intrathecal therapy of carcinomatous meningitis.

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