Vol 6, No 1 (2010)
Review paper
Published online: 2010-05-06
Sequential therapy with focus on TKI’s in treatment of patients with metastatic renal cell carcinoma
Onkol. Prak. Klin 2010;6(1):21-28.
Abstract
Till recently the immunotherapy was the only option of systemic treatment in metastatic renal-cell carcinoma
(mRCC) patients - in Poland based on interferon a, rarely interleukin 2. Unfortunately this method of
therapy has limited efficiacy nevertheless the potential generation of complete remissions (low percentage
of treated patients), usually equal to cure, is the unquestionable advantage of its use. Novel drugs
- thyrosine and serine-threonine kinases inhibitors and monoclonal antybodies have been broadly used
in clinical practice for several years now. Due to their use the objective responses are seen more often.
The problem is that despite the fact they significantly prolong progression free survival, their impact on
overall survival is not clear and complete remissions are casuistic. Still the aim of pharmacotherapy is to
decelerate the tumor growth and to delay the moment it reaches its critical burden. In fact the cure is still
impossible. The sequential therapy is the option to improve clinical benefit of pharmacotherapy in this
disease. There is growing body of evidence supporting clinical value of this strategy. The paper is the
short discussion of the problem.
Keywords: metastatic renal cell cancertargeted therapythyrosine and serine-threonine kinases inhibitorsmonoclonal antybodiessequential therapy
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