Vol 6, No 6 (2010)
Review paper
Published online: 2011-02-24
Hormonotherapy in patients with HER2-positive breast cancer
Onkol. Prak. Klin 2010;6(6):301-310.
Abstract
About 75% of breast cancers are estrogen receptor-positive. Approximately 10% of them is HER2-positive
as well. Palliative and adjuvant hormonotherapy is an effective treatment, which prolongs survival
in women with hormonal receptor-positive breast cancer. HER2 overexpression despite of being
a negative prognostic factor also predicts reduced benefit from hormonotherapy.
The reason for that is that signaling of estrogen receptors crosstalks with signal pathways of growth factor receptors. This phenomenon may lead to the development of hormonoresistance.
The present article is a review of the most important clinical trials of hormonotherapy and combined hormonal and anti-HER2 treatment in patients with co-expression of steroid receptors and HER2.
The reason for that is that signaling of estrogen receptors crosstalks with signal pathways of growth factor receptors. This phenomenon may lead to the development of hormonoresistance.
The present article is a review of the most important clinical trials of hormonotherapy and combined hormonal and anti-HER2 treatment in patients with co-expression of steroid receptors and HER2.
Onkol. Prak. Klin. 2010; 6, 6: 301–310
Keywords:
breast cancerestrogen receptorHER2hormonotherapytrastuzumablapatinib
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