Vol 7, No 4 (2011)
Review paper
Published online: 2011-10-26
Epidermal growth factor receptor (EGFR) inhibition on non-small-cell lung cancer treatment
Onkol. Prak. Klin 2011;7(4):177-182.
Abstract
Non small cell lung cancer (NSCLC) remains a significant clinical and social problem. In the last period
there has been a steady increase a incidence in women and men. Results of surgical treatment, radiotherapy
and chemotherapy have reached a plateau. Perspectives for pharmacological treatment of NSCLC
determines understanding the molecular mechanisms responsible for tumor growth and resistance.
The introduction of molecularly targeted drugs is an important step in the treatment of NSCLC. Targeted
treatment includes the use of monoclonal antibodys, anti-angiogenic treatment and small molecule tyrosine
kinase inhibitors. Identity of predictive factors plays a huge role for targeting treatment optimization.
Onkol. Prak. Klin. 2011; 7, 4: 177–182
Onkol. Prak. Klin. 2011; 7, 4: 177–182
Keywords: non-small-cell lung cancertarget therapyepidermal growth factor receptortyrosine kinase inhibitorserlotinibgefitinibcetuximab