open access

Vol 7, No 4 (2011)
Review paper
Published online: 2011-10-26
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The therapy interfering EGFR activation in breast cancer patients

Piotr Tokajuk, Bogumiła Czartoryska-Arłukowicz, Marek Z. Wojtukiewicz
Onkol. Prak. Klin 2011;7(4):159-176.

open access

Vol 7, No 4 (2011)
REVIEW ARTICLES
Published online: 2011-10-26

Abstract

HER2 receptor overexpression is present in about 20% of breast cancer patients and is associated with aggressive course of the disease and shortening of disease-free and overall survival. Simultaneously, overexpression of this receptor or HER2 gene amplification is a predictive factor for treatment with trastuzumab. Trastuzumab is a monoclonal antibody directed against extracellular domain of HER2 receptor. Trastuzumab binding with this receptor on the cancer cell’s surface results in an inhibition of intracellular signaling pathway associated with HER2 receptor. It has been shown that trastuzumab in combination with chemotherapy significantly improved response rate and prolonged overall survival of advanced HER2-positive breast cancer patients, compared to patients treated exclusively with chemotherapy. Moreover, addition of trastuzumab to neoadjuvant chemotherapy leads to pathological complete remission in a significant proportion of HER2-positive locally advanced breast cancer patients. Furthermore, use of trastuzumab in combination with adjuvant chemotherapy in HER2-positive early breast cancer patients was associated with about 50% reduction of risk of disease recurrence and about 30% decrease in the risk of death. Most importantly, introduction of trastuzumab into clinical practice has opened a new avenue of research focused on targeted therapy directed against molecular targets located in cancer cell. Since than, intracellular signaling pathway associated with HER2 receptor has been the subject of thousands of experimental and clinical studies. The ultimate aim of these studies is a steady improvement in treatment results and prolongation of survival of patients suffering from this aggressive form of breast cancer. As a result, introduction into clinical practice of new drugs that are active in the treatment of trastuzumab- refractory patients is anticipated in the near future. A plethora of new drugs are at various stages of clinical development at that moment. In this paper we present a review of data that were obtained in controlled clinical trials in recent years, regarding the most important aspects of therapies interfering with HER2 receptor in HER2-positive breast cancer patients.
Onkol. Prak. Klin. 2011; 7, 4: 159–176

Abstract

HER2 receptor overexpression is present in about 20% of breast cancer patients and is associated with aggressive course of the disease and shortening of disease-free and overall survival. Simultaneously, overexpression of this receptor or HER2 gene amplification is a predictive factor for treatment with trastuzumab. Trastuzumab is a monoclonal antibody directed against extracellular domain of HER2 receptor. Trastuzumab binding with this receptor on the cancer cell’s surface results in an inhibition of intracellular signaling pathway associated with HER2 receptor. It has been shown that trastuzumab in combination with chemotherapy significantly improved response rate and prolonged overall survival of advanced HER2-positive breast cancer patients, compared to patients treated exclusively with chemotherapy. Moreover, addition of trastuzumab to neoadjuvant chemotherapy leads to pathological complete remission in a significant proportion of HER2-positive locally advanced breast cancer patients. Furthermore, use of trastuzumab in combination with adjuvant chemotherapy in HER2-positive early breast cancer patients was associated with about 50% reduction of risk of disease recurrence and about 30% decrease in the risk of death. Most importantly, introduction of trastuzumab into clinical practice has opened a new avenue of research focused on targeted therapy directed against molecular targets located in cancer cell. Since than, intracellular signaling pathway associated with HER2 receptor has been the subject of thousands of experimental and clinical studies. The ultimate aim of these studies is a steady improvement in treatment results and prolongation of survival of patients suffering from this aggressive form of breast cancer. As a result, introduction into clinical practice of new drugs that are active in the treatment of trastuzumab- refractory patients is anticipated in the near future. A plethora of new drugs are at various stages of clinical development at that moment. In this paper we present a review of data that were obtained in controlled clinical trials in recent years, regarding the most important aspects of therapies interfering with HER2 receptor in HER2-positive breast cancer patients.
Onkol. Prak. Klin. 2011; 7, 4: 159–176
Get Citation

Keywords

HER2; HER2-positive breast cancer; targeted therapy; trastuzumab; lapatinib; pertuzumab; neratinib

About this article
Title

The therapy interfering EGFR activation in breast cancer patients

Journal

Oncology in Clinical Practice

Issue

Vol 7, No 4 (2011)

Article type

Review paper

Pages

159-176

Published online

2011-10-26

Bibliographic record

Onkol. Prak. Klin 2011;7(4):159-176.

Keywords

HER2
HER2-positive breast cancer
targeted therapy
trastuzumab
lapatinib
pertuzumab
neratinib

Authors

Piotr Tokajuk
Bogumiła Czartoryska-Arłukowicz
Marek Z. Wojtukiewicz

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