open access

Vol 17, No 3 (2021)
Case report
Published online: 2021-04-20
Get Citation

Early-stage gastric cancer presenting with tripe palm and acanthosis nigricans

Mehmet Zahid Kocak, Murat Araz, Mustafa Korkmaz, Aykut Demirkiran
DOI: 10.5603/OCP.2021.0014
·
Oncol Clin Pract 2021;17(3):132-134.

open access

Vol 17, No 3 (2021)
CASE REPORTS
Published online: 2021-04-20

Abstract

Tripe palm is a rare cutaneous paraneoplastic syndrome that can be overlooked and frequently appears with acanthosis nigricans. If tripe palm and acanthosis nigricans occur in a patient together, gastric cancer should come to mind. A 50-year-old female patient had signs of abdominal pain and velvety thickening in the palms and soles. Tripe palm and acanthosis nigricans were considered as paraneoplastic syndrome after other benign causes were excluded. It was determined that the underlying malignancy was gastric cancer. After neoadjuvant FLOT chemotherapy regimen, gastrectomy was performed, and the patient received adjuvant chemotherapy. With the recognition of tripe palm, a rare cutaneous paraneoplastic syndrome, patients can be diagnosed and treated early.

Abstract

Tripe palm is a rare cutaneous paraneoplastic syndrome that can be overlooked and frequently appears with acanthosis nigricans. If tripe palm and acanthosis nigricans occur in a patient together, gastric cancer should come to mind. A 50-year-old female patient had signs of abdominal pain and velvety thickening in the palms and soles. Tripe palm and acanthosis nigricans were considered as paraneoplastic syndrome after other benign causes were excluded. It was determined that the underlying malignancy was gastric cancer. After neoadjuvant FLOT chemotherapy regimen, gastrectomy was performed, and the patient received adjuvant chemotherapy. With the recognition of tripe palm, a rare cutaneous paraneoplastic syndrome, patients can be diagnosed and treated early.

Get Citation

Keywords

tripe palm; acanthosis nigricans; gastric cancer; paraneoplastic syndrome

About this article
Title

Early-stage gastric cancer presenting with tripe palm and acanthosis nigricans

Journal

Oncology in Clinical Practice

Issue

Vol 17, No 3 (2021)

Article type

Case report

Pages

132-134

Published online

2021-04-20

DOI

10.5603/OCP.2021.0014

Bibliographic record

Oncol Clin Pract 2021;17(3):132-134.

Keywords

tripe palm
acanthosis nigricans
gastric cancer
paraneoplastic syndrome

Authors

Mehmet Zahid Kocak
Murat Araz
Mustafa Korkmaz
Aykut Demirkiran

References (9)
  1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6): 394–424.
  2. Chon HJ, Hyung WJ, Kim C, et al. Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma: Stage Adjusted Analysis From a Single High-volume Center in Asia. Ann Surg. 2017; 265(5): 946–953.
  3. Al-Batran SE, Homann N, Pauligk C, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. The Lancet. 2019; 393(10184): 1948–1957.
  4. Schadt CR. The cutaneous manifestations of gastrointestinal malignancy. Semin Oncol. 2016; 43(3): 341–346.
  5. Cohen P, Grossman M, Silvers D, et al. Tripe palms and cancer. Clinics in Dermatology. 1993; 11(1): 165–173.
  6. Gheeraert P, Goens J, Schwartz RA, et al. Florid cutaneous papillomatosis, malignant acanthosis nigricans, and pulmonary squamous cell carcinoma. Int J Dermatol. 1991; 30(3): 193–197.
  7. Ehst BD, Minzer-Conzetti K, Swerdlin A, et al. Cutaneous manifestations of internal malignancy. Curr Probl Surg. 2010; 47(5): 384–445.
  8. Cohen PR, Grossman ME, Almeida L, et al. Tripe palms and malignancy. J Clin Oncol. 1989; 7(5): 669–678.
  9. Thiers BH, Sahn RE, Callen JP. Cutaneous manifestations of internal malignancy. CA Cancer J Clin. 2009; 59(2): 73–98.

Important: This website uses cookies. More >>

The cookies allow us to identify your computer and find out details about your last visit. They remembering whether you've visited the site before, so that you remain logged in - or to help us work out how many new website visitors we get each month. Most internet browsers accept cookies automatically, but you can change the settings of your browser to erase cookies or prevent automatic acceptance if you prefer.

Wydawcą serwisu jest  "Via Medica sp. z o.o." sp.k., ul. Świętokrzyska 73, 80–180 Gdańsk

tel.:+48 58 320 94 94, faks:+48 58 320 94 60, e-mail:  viamedica@viamedica.pl