Vol 17, No 3 (2021)
Case report
Published online: 2021-04-20

open access

Page views 787
Article views/downloads 1128
Get Citation

Connect on Social Media

Connect on Social Media

Early-stage gastric cancer presenting with tripe palm and acanthosis nigricans

Mehmet Zahid Kocak1, Murat Araz1, Mustafa Korkmaz1, Aykut Demirkiran1
Oncol Clin Pract 2021;17(3):132-134.

Abstract

Tripe palm is a rare cutaneous paraneoplastic syndrome that can be overlooked and frequently appears with acanthosis nigricans. If tripe palm and acanthosis nigricans occur in a patient together, gastric cancer should come to mind. A 50-year-old female patient had signs of abdominal pain and velvety thickening in the palms and soles. Tripe palm and acanthosis nigricans were considered as paraneoplastic syndrome after other benign causes were excluded. It was determined that the underlying malignancy was gastric cancer. After neoadjuvant FLOT chemotherapy regimen, gastrectomy was performed, and the patient received adjuvant chemotherapy. With the recognition of tripe palm, a rare cutaneous paraneoplastic syndrome, patients can be diagnosed and treated early.

Article available in PDF format

View PDF Download PDF file

References

  1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018; 68(6): 394–424.
  2. Chon HJ, Hyung WJ, Kim C, et al. Differential Prognostic Implications of Gastric Signet Ring Cell Carcinoma: Stage Adjusted Analysis From a Single High-volume Center in Asia. Ann Surg. 2017; 265(5): 946–953.
  3. Al-Batran SE, Homann N, Pauligk C, et al. Perioperative chemotherapy with fluorouracil plus leucovorin, oxaliplatin, and docetaxel versus fluorouracil or capecitabine plus cisplatin and epirubicin for locally advanced, resectable gastric or gastro-oesophageal junction adenocarcinoma (FLOT4): a randomised, phase 2/3 trial. The Lancet. 2019; 393(10184): 1948–1957.
  4. Schadt CR. The cutaneous manifestations of gastrointestinal malignancy. Semin Oncol. 2016; 43(3): 341–346.
  5. Cohen P, Grossman M, Silvers D, et al. Tripe palms and cancer. Clinics in Dermatology. 1993; 11(1): 165–173.
  6. Gheeraert P, Goens J, Schwartz RA, et al. Florid cutaneous papillomatosis, malignant acanthosis nigricans, and pulmonary squamous cell carcinoma. Int J Dermatol. 1991; 30(3): 193–197.
  7. Ehst BD, Minzer-Conzetti K, Swerdlin A, et al. Cutaneous manifestations of internal malignancy. Curr Probl Surg. 2010; 47(5): 384–445.
  8. Cohen PR, Grossman ME, Almeida L, et al. Tripe palms and malignancy. J Clin Oncol. 1989; 7(5): 669–678.
  9. Thiers BH, Sahn RE, Callen JP. Cutaneous manifestations of internal malignancy. CA Cancer J Clin. 2009; 59(2): 73–98.