open access

Vol 15, No 2 (2019)
Review paper
Published online: 2019-05-17
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Benefits and difficulties during brain radiotherapy planning with hippocampus sparing

Monika Konopka-Filippow, Ewa Sierko, Marek Z. Wojtukiewicz
DOI: 10.5603/OCP.2019.0019
·
Oncol Clin Pract 2019;15(2):104-110.

open access

Vol 15, No 2 (2019)
REVIEW ARTICLES
Published online: 2019-05-17

Abstract

Radiotherapy (RT) is frequently used in the treatment of primary and secondary brain tumours, as well as in prophylactic cranial irradiation (PCI). The hippocampus plays a key function in the process of remembering, relaying information from short-term to long-term memory as consolidation, and spatial orientation. Sparing the hippocampus during brain radiotherapy aims to prevent hippocampal-dependent cognitive function deterioration. This procedure requires a good knowledge of the brain’s radiological anatomy and use of modern radiotherapy techniques.

This article presents the validity of hippocampus sparing during brain radiotherapy, the potential benefits of using this procedure, available clinical premises regarding patient qualification, and technical difficulties in the brain’s RT planning with hippocampus avoidance.

Abstract

Radiotherapy (RT) is frequently used in the treatment of primary and secondary brain tumours, as well as in prophylactic cranial irradiation (PCI). The hippocampus plays a key function in the process of remembering, relaying information from short-term to long-term memory as consolidation, and spatial orientation. Sparing the hippocampus during brain radiotherapy aims to prevent hippocampal-dependent cognitive function deterioration. This procedure requires a good knowledge of the brain’s radiological anatomy and use of modern radiotherapy techniques.

This article presents the validity of hippocampus sparing during brain radiotherapy, the potential benefits of using this procedure, available clinical premises regarding patient qualification, and technical difficulties in the brain’s RT planning with hippocampus avoidance.

Get Citation

Keywords

hippocampus sparing; brain radiotherapy; cognitive function

About this article
Title

Benefits and difficulties during brain radiotherapy planning with hippocampus sparing

Journal

Oncology in Clinical Practice

Issue

Vol 15, No 2 (2019)

Article type

Review paper

Pages

104-110

Published online

2019-05-17

DOI

10.5603/OCP.2019.0019

Bibliographic record

Oncol Clin Pract 2019;15(2):104-110.

Keywords

hippocampus sparing
brain radiotherapy
cognitive function

Authors

Monika Konopka-Filippow
Ewa Sierko
Marek Z. Wojtukiewicz

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