open access

Vol 12, No 2 (2016)
Review paper
Published online: 2016-08-04
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Metronomic chemotherapy in non-small-cell lung cancer — current status

Magdalena Knetki-Wróblewska, Maciej Krzakowski
Oncol Clin Pract 2016;12(2):37-42.

open access

Vol 12, No 2 (2016)
REVIEW ARTICLES
Published online: 2016-08-04

Abstract

Chemotherapy remains a standard treatment of advanced non-small-cell lung cancer. Metronomic chemotherapy – frequent administration of low-dose cytotoxic agents – may be a new option with minimal toxicity. This method may have complex mechanisms of action — the antiangiogenic effects and modulation of the immune system are crucial. Vinorelbine could be an option for non-small-cell lung cancer patients because of it has favourable safety profile and the oral form of the drug is easy to administer. There are some studies documenting the clinical activity of oral vinorelbine in advanced non-small-cell lung cancer patients. However, further prospective studies are necessary to assess the place of metronomic chemotherapy in clinical practice.

Abstract

Chemotherapy remains a standard treatment of advanced non-small-cell lung cancer. Metronomic chemotherapy – frequent administration of low-dose cytotoxic agents – may be a new option with minimal toxicity. This method may have complex mechanisms of action — the antiangiogenic effects and modulation of the immune system are crucial. Vinorelbine could be an option for non-small-cell lung cancer patients because of it has favourable safety profile and the oral form of the drug is easy to administer. There are some studies documenting the clinical activity of oral vinorelbine in advanced non-small-cell lung cancer patients. However, further prospective studies are necessary to assess the place of metronomic chemotherapy in clinical practice.

Get Citation

Keywords

metronomic, NSCLC, vinorelbine

About this article
Title

Metronomic chemotherapy in non-small-cell lung cancer — current status

Journal

Oncology in Clinical Practice

Issue

Vol 12, No 2 (2016)

Article type

Review paper

Pages

37-42

Published online

2016-08-04

Bibliographic record

Oncol Clin Pract 2016;12(2):37-42.

Keywords

metronomic
NSCLC
vinorelbine

Authors

Magdalena Knetki-Wróblewska
Maciej Krzakowski

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