Fulvestrant endocrine therarapy in patient with CNS dissemination of breast cancer

Abstract

With constant improvement of medicine we can diagnose and treat breast cancer in more and more effective way. Unfortunately, due to low level of social knowledge and consciousness about our own health status in our country many women visit physicians too late, when the disease is difficult to cope with. For this and other reasons there is a substantial number of patients that cannot be fully cured. In many of them cancer spreads, sometimes involving brain metastases, which are considered to be one of the most unfavorable risk factors and usually causes death in shorter time perspective than other localization of dissemination. It is often followed by deterioration of patients’ condition and appearance of some kind of neurological deficit. It can further limit possibility of treatment, especially prescribing cytotoxic chemotherapy. Usually well-tolerated endocrine therapy is a valuable option here and it can stabilize disease. This case study is about encoraging effect of fulvestrant treatment as a third-line endocrine therapy in patient with breast cancer with dissemination to central nervous system.