open access

Vol 12, No 1 (2016)
Review paper
Published online: 2016-05-02
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Afatinib — current applications and perspectives

Maciej Krzakowski
Oncol Clin Pract 2016;12(1):12-17.

open access

Vol 12, No 1 (2016)
REVIEW ARTICLES
Published online: 2016-05-02

Abstract

The use of epidermal growth factor receptor tyrosine kinase inhibitors resulted in significantly improved quality of life and survival prolongation in patients with advanced lung adenocarcinoma harbouring activating EGFR mutations. Tyrosine kinase inhibitors — compared with chemotherapy — produce less treatment-related adverse effects. Tyrosine kinase inhibitors may have either reversible or irreversible activity, which may be important for their use in clinical practice. This paper presents current knowledge and potential use of afatinib in non-small cell lung cancer patients.

Abstract

The use of epidermal growth factor receptor tyrosine kinase inhibitors resulted in significantly improved quality of life and survival prolongation in patients with advanced lung adenocarcinoma harbouring activating EGFR mutations. Tyrosine kinase inhibitors — compared with chemotherapy — produce less treatment-related adverse effects. Tyrosine kinase inhibitors may have either reversible or irreversible activity, which may be important for their use in clinical practice. This paper presents current knowledge and potential use of afatinib in non-small cell lung cancer patients.

Get Citation

Keywords

non-small-cell lung cancer; epidermal growth factor receptor; irreversible tyrosine kinase inhibitor; afatinib

About this article
Title

Afatinib — current applications and perspectives

Journal

Oncology in Clinical Practice

Issue

Vol 12, No 1 (2016)

Article type

Review paper

Pages

12-17

Published online

2016-05-02

Bibliographic record

Oncol Clin Pract 2016;12(1):12-17.

Keywords

non-small-cell lung cancer
epidermal growth factor receptor
irreversible tyrosine kinase inhibitor
afatinib

Authors

Maciej Krzakowski

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