open access

Vol 11, No 5 (2015)
Review paper
Published online: 2016-02-17
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The role of boost in hypofractionated irradiation after breast-conserving surgery

Marcin Sinacki, Krystyna Serkies, Jacek Jassem
Oncol Clin Pract 2015;11(5):267-271.

open access

Vol 11, No 5 (2015)
REVIEW ARTICLES
Published online: 2016-02-17

Abstract

Adjuvant radiotherapy after surgical treatment constitutes an indispensable part of breast-conserving therapy (BCT) in early breast cancer. The standard dose to the whole breast in BCT is 50 Gy delivered in 2 Gy fractions, with or without a boost dose to the tumour bed. A decreased risk of local recurrence, particularly in younger patients, as a result of a boost dose has been confirmed in a large randomised trial. Recently, mildly hypofractionated schedules of radiotherapy are being used more frequently in BCT. The indications and form of boost radiotherapy in hypofractionated schedules have not been fully determined. This article reviews randomised trials addressing hypofractionated radiotherapy in BCT, and particularly the role of a boost dose. We also present current recommendations in these areas.

Abstract

Adjuvant radiotherapy after surgical treatment constitutes an indispensable part of breast-conserving therapy (BCT) in early breast cancer. The standard dose to the whole breast in BCT is 50 Gy delivered in 2 Gy fractions, with or without a boost dose to the tumour bed. A decreased risk of local recurrence, particularly in younger patients, as a result of a boost dose has been confirmed in a large randomised trial. Recently, mildly hypofractionated schedules of radiotherapy are being used more frequently in BCT. The indications and form of boost radiotherapy in hypofractionated schedules have not been fully determined. This article reviews randomised trials addressing hypofractionated radiotherapy in BCT, and particularly the role of a boost dose. We also present current recommendations in these areas.

Get Citation

Keywords

breast cancer, breast conserving therapy, hypofractionated radiotherapy, boost dose

About this article
Title

The role of boost in hypofractionated irradiation after breast-conserving surgery

Journal

Oncology in Clinical Practice

Issue

Vol 11, No 5 (2015)

Article type

Review paper

Pages

267-271

Published online

2016-02-17

Bibliographic record

Oncol Clin Pract 2015;11(5):267-271.

Keywords

breast cancer
breast conserving therapy
hypofractionated radiotherapy
boost dose

Authors

Marcin Sinacki
Krystyna Serkies
Jacek Jassem

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