open access
Prognosis and biology in esthesioneuroblastoma: the emerging role of Hyams grading system
open access
Abstract
Esthesioneuroblastoma is a sinonasal tumor with distinct clinicopathologic features, multiple facets, and a spectrum of behavior. Characterization of this disease is challenging, and clinically, several staging systems have been used with no consensus on a single scheme. Recently, the Hyams histological grading system has emerged as a promising prognostication tool that offers an added value to stage. This review addresses prognosis and biology in esthesioneuroblastoma. More specifically, we sought to present a critical appraisal on the value of each of these stratification systems, stage vs. grade, in identifying risk groups and guiding management.
Abstract
Esthesioneuroblastoma is a sinonasal tumor with distinct clinicopathologic features, multiple facets, and a spectrum of behavior. Characterization of this disease is challenging, and clinically, several staging systems have been used with no consensus on a single scheme. Recently, the Hyams histological grading system has emerged as a promising prognostication tool that offers an added value to stage. This review addresses prognosis and biology in esthesioneuroblastoma. More specifically, we sought to present a critical appraisal on the value of each of these stratification systems, stage vs. grade, in identifying risk groups and guiding management.
Keywords
esthesioneuroblastoma, olfactory neuroblastoma, Hyams, Kadish, Morita, stage, grade, prognosis, outcome
About this articleTitle
Prognosis and biology in esthesioneuroblastoma: the emerging role of Hyams grading system
Journal
Issue
Pages
53-59
Published online
2015-03-12
Bibliographic record
Onkol. Prak. Klin 2015;11(1):53-59.
Keywords
esthesioneuroblastoma
olfactory neuroblastoma
Hyams
Kadish
Morita
stage
grade
prognosis
outcome
Authors
Rami E. Saade
Ehab Y. Hanna
Diana Bell