open access

Vol 11, No 2 (2015)
Case report
Published online: 2015-05-20
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Effective sequential chemoradiotherapy of a patient with locally advanced melanoma of the naso-ethmoidal massive

Kamila Patrycja Tabaka, Krystian Kidrycki, Marek Wojtukiewicz, Ewa Sierko
Onkol. Prak. Klin 2015;11(2):115-119.

open access

Vol 11, No 2 (2015)
CASE REPORTS
Published online: 2015-05-20

Abstract

Mucosal melanomas are rare neoplasms. They account for approximately 0.5–2% of all melanomas. The treatment of choice is radical surgical resection followed by radiotherapy and/or chemotherapy. 5-year survival rate in mucosal melanomas is only 17.1%. Case report: 54-year-old patient presented with a 50 × 36 mm mucosal melanoma located within the left maxillary sinus, ethmoid sinus and upper-middle part of the nasal cavity. Clinical stage of the disease was estimated to T4bN1M0. The patient was treated with chemotherapy (CT) according to the BOLD program: bleomycin 8 mg/m2, vincristine 1 mg/m2, lomustine 44 mg/m2, dacarbazine 250 mg/m2 — 5 courses given every 4 weeks. Because of a good tumor response was observed 3D megavoltage radiation therapy (RT) was administered to the tumor bed in total dose of 52.8 Gy in 20 fractions given 3 times a week. Complete remission of the tumor was achieved. Currently, after 6 years, there is no evidence of active disease. The quality of life of the patient remains satisfactory. Despite the advanced clinical stage of melanoma at presentation, sequential chemoradiotherapy was an effective treatment for the mucosal melanoma patient.

Abstract

Mucosal melanomas are rare neoplasms. They account for approximately 0.5–2% of all melanomas. The treatment of choice is radical surgical resection followed by radiotherapy and/or chemotherapy. 5-year survival rate in mucosal melanomas is only 17.1%. Case report: 54-year-old patient presented with a 50 × 36 mm mucosal melanoma located within the left maxillary sinus, ethmoid sinus and upper-middle part of the nasal cavity. Clinical stage of the disease was estimated to T4bN1M0. The patient was treated with chemotherapy (CT) according to the BOLD program: bleomycin 8 mg/m2, vincristine 1 mg/m2, lomustine 44 mg/m2, dacarbazine 250 mg/m2 — 5 courses given every 4 weeks. Because of a good tumor response was observed 3D megavoltage radiation therapy (RT) was administered to the tumor bed in total dose of 52.8 Gy in 20 fractions given 3 times a week. Complete remission of the tumor was achieved. Currently, after 6 years, there is no evidence of active disease. The quality of life of the patient remains satisfactory. Despite the advanced clinical stage of melanoma at presentation, sequential chemoradiotherapy was an effective treatment for the mucosal melanoma patient.

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Keywords

mucosal melanoma, naso-ethmoidal massive, long-term survival, sequential chemoradiotherapy

About this article
Title

Effective sequential chemoradiotherapy of a patient with locally advanced melanoma of the naso-ethmoidal massive

Journal

Oncology in Clinical Practice

Issue

Vol 11, No 2 (2015)

Article type

Case report

Pages

115-119

Published online

2015-05-20

Bibliographic record

Onkol. Prak. Klin 2015;11(2):115-119.

Keywords

mucosal melanoma
naso-ethmoidal massive
long-term survival
sequential chemoradiotherapy

Authors

Kamila Patrycja Tabaka
Krystian Kidrycki
Marek Wojtukiewicz
Ewa Sierko

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